纤维蛋白_原_纤维蛋白_原_降解产物及其基序拮抗剂和动脉粥样硬化_曹勇军.pdfVIP

# 290 # 20064 14 4 Int J Cerebrovasc Dis, April 2006, Vol 14, No. 4 # # 纤维蛋白(原) 纤维蛋白(原) 降解产物及其 基序拮抗剂与动脉粥样硬化 曹勇军,钱进军, 刘春风 , () ( ) ,( ) () ;( ); ; Fibrin(ogen), Its Degradation Products andtheir Motif Antagonist and Atherosclerosis Yong-Jun Cao, Jin-Jun Qian, Chun-FengLiu Department of Neurology, the Second Affiliated ospital of Soochow University, Suzhou 215004, China Abstract Atherosclerosis is the ost i portant pathological basis of ische ic cerebro- vasculardiseases. As an independent risk factor of atherosclerosis, fibrin(ogen) and its degradation productsinvolve in theprocesses of thefor ation anddevelop ent of ather- osclerosis. This articlereviewstherelationship betweenfibrin(ogen) and/ or its degrada- tion products and atherosclerosis, and also introduces the develop ent and application prospectsfor so especific otif antagonists of fibrin(ogen) in the treat ent of athero- sclerosis and ische ic cerebrovasculardiseases. KeyWords fibrin(ogen) ; fibrin(ogen) degradation product; atherosclerosis; ische ic cerebrovascular disease (atherosclerosis, AS) D(67 kD),3 A E , (33 kD)Fg (f-i , brin, Fb), FgAB 116 14 , ,(fibrinogen, Fg)AS (fibrinopeptide, FP)A FPB [1,2] , Fg ,FPA FPBAA BB [3] AS , (fibrin ono er, F ) 2+ 1 Fg Ca ,ÚÓa F E- Fg2%~ 3%, , F C- , 340 @ ,C--E- 3 , F 10 (340 kD) Fg2 , [4] 3 , AABB C,3 (ABC) ,Fb ,2 , FgFb(F ) Fb , Fg () (fibrinogen degradation product, FDP)Fg :215004 FbEDY X , Fb