上皮间质转化和肿瘤转移的研究进展.pdfVIP

20 10 2 17 4 CH IN J CA N CE R PR EV T R EA T , February 20 10, V ol. 17 N o . 4 311 综述讲座 1, 2 1 燕慧 , 王捷 1. 广州军区广州总医院医学实验科, 广东广州510010 2. 华南理工大学生物科学与工程学院, 广东广州5 10006 Epithelialmesenchymal t ransitions and tumor metastasis 1, 2 1 YAN H ui , WA N G Jie 1. Dep artment of of Medical R esearch, Guangzhou General H osp ital of Guangzhou Military ommand, Guangzhou 5 10010, P .R. hina 2. School of Bioscience and B ioengineering , South hina Univ ersity of Technology, Guangzhou 5 10006, P.R . hina ! : 总结上皮间质转化( EM T ) 的 [ABSTRACT] OBJECTIVE : T o rev iew reg ula io n mechanism s 调节机制并揭示其与肿瘤转移的关系: of EM T and r ev eal he rela io nship be w een EM T and umor me 应用 PubM ed 检索 CN K I 中国期刊全文数 as asis . METHODS: T he li era ure abo u EM T and umor me 据库检索系统, 以上皮间质转化和肿瘤转移为 as asis w as sear ched in PubM ed and CN K I fr om 2004 o 200 8. 关键词检索2004 - 2008 年的相关文献纳入 Re rieval cr i er ion : 1) he regula ion mechanism s o f EM T ; 2) he 标准: 1) 上皮间质转化调节机制的研究; 2) 上 rela ionship be w een EM T and umor me as asis . A bou 60 ar i 皮间质转化与肿瘤转移的关系根据纳入标 cles w er e selec ed and acco rding o he re r ieval cr i erion 33 w er e 准, 精选60 篇文献, 最后纳入分析33 篇文献 ref ined f inally. RESULTS: EM T ex is s in many physio log ical : EM T 存在于人体多个生理和病理过程 and pa ho lo gical pr ocesses in human bo dy . T he regula ion mech 中EM T 的发生涉 E钙连蛋 白T G F anism s of EM T inv olve Ecadherins, r ansfor ming g ro w h f ac or w n 信号通路转录因子以 micro RN A 等机 , w n sig nal, r anscr ip ion f ac o rs, micr oRN A and so on . Cells 制的调节, 转化为 EM T 的细胞具有干细胞样 under go ing EM T possess s em cells pro per y. CONCLUSI ONS: 属性: EM T 与肿瘤细胞的转移关系密