BLT2受体拮抗剂的体外抗肿瘤效应研究.pdfVIP

wasexpressedinalltheninetumorcelllines.LY255283inhibitedtheproliferationofthenine tumorcelllineswiththeIC50valuesat0.21,11.17,1.28,5.9,7.9,1.59,0.14,1.25and31.28μM, respectively.TheapoptoticratesofMCF-7cellsinducedbyLY255283at1μMand10μMwere 20.47％ and31.28％,respectively,significantlyincreased(P＜0.01)comparedwiththatofboth blank(8.66％)andDMSO(11.71％)controlgroups.ConclusionBLT2receptorsareexpressedin thedetectedninehumantumorcelllines,anditsspecificantagonistLY255283exertssignificant inhibitoryeffectsontheproliferationoftumorcellsbyinducingcellapoptosis. Keywords:leukotrieneB4;BLT2;