茵栀黄口服液联合蓝光照射治疗新生儿高胆红素血症临床观察.docVIP

茵栀黄口服液联合蓝光照射治疗新生儿高胆红素血症临床观察 王羲之（广州医科大学） [摘要] 目的：观察茵栀黄口服液联合蓝光照射治疗新生儿高胆红素血症的疗效及安全性。方法：将2012年5月至2013年5月我院新生儿科收治的足月新生儿高胆红素血症患儿116例，按随机数表法分为治疗组和对照组各58例。两组均采用常规综合治疗及蓝光照射治疗，治疗组加用茵栀黄口服液治疗，每次5 mL，每天2次，连用7 d，比较两组住院时间，分别于治疗前、治疗后3 d、治疗后7 d采血检测血清总胆红素下降情况并进行统计学分析。结果：治疗组总有效率94.8%，高于观察组的79.2%，两组比较差异有统计学意义（χ2=6.20，P0.05)；治疗组治疗3 d、7 d血清胆红素水平均明显低于对照组（P0.01），胆红素恢复正常时间和住院时间较对照组明显缩短，差异有统计学意义（P0.01）；两组患儿均未见明显不灵反应。结论：茵栀黄口服液联合蓝光照射治疗新生儿高胆红素血症疗效显著，能缩短疗程，值得临床推广应用。 [关键词]茵栀黄口服液；蓝光照射；新生儿；高胆红素血症 [中图分类号]R722.1 [文献标识码]A [文章编号]1672-108X(2014)00-0000-00 Clinical Observation On Yinzhihuang Oral Solution Combined with Blu Ray Irradiation For Treating of Neonatal Hyperbilirubinemia [Abstract] Objective: To observe the clinical observation of clinical curative effect of neonatal hyperbilirubinemia of Yinzhihuang oral solution combined with blue light irradiation. Methods: The patients were divided in 116 neonates with hyperbilirubinemia from 2012 May to 2013 May in our hospital neonatal according to the stochastic indicator were treated as treatment group (58 cases) and control group (58 cases), two groups were treated with routine comprehensive measures and blue light treatment, treatment group were treated with Yinzhihuang oral solution treatment, 5 mL/times, 2 times/d, application 7 days, compare two groups of length of hospital stay, respectively before and after treatment for 3 days, 7 days after treatment, blood detection of serum total bilirubin decreased situation for statistical analysis. Results: The treatment group total effective rate is high in the observation group (94.8% vs 79.2%), the difference was statistically significant (chi-square =6.20, P0.05), treatment group 3 days, 7 days serum bilirubin level improvement is better than the control group (t= 13.473, t=18.477, P0.01), bilirubin restored to normal time and hospital stay was significantly shortened, was statistically significant difference (t= 8.341, t=6.386, P0.01), two groups of children have no obvious side e