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Chemistry of Natural Compounds, Vol. 47, No. 4, September, 2011 [Russian original No. 4, July–August, 2011]
STRUCTURE ELUCIDATION AND NMR ASSIGNMENTS
FOR TWO NEW QUINONES FROM FRUCTUS
RHODOMYRTI OF Rhodomyrtus tomentosa
1,2 3 1*
Tao Chen, Chuguo Yu, and Bolun Yang UDC 547.972
Two new quinones, 1,4,7-trihydroxy-2-methoxy-6-methylanthracene-9,10-dione (1) and compound 2, were
isolated from fructus rhodomyrti of Rhodomyrtus tomentosa (Ari.) Hassk., which was collected from
Guangdong Province. The structures were elucidated by 1D, 2D NMR, and HR-EI-MS spectroscopy methods.
The cytotoxic activities of two compounds in vitro were tested. Compound 1 showed cytotoxicity against KB
and KBv200 cell lines with IC50 of 17.1 and 19.5 g/mL, and compound 2 with IC50 of 18.1 and 25.4 g/mL,
respectively.
Keywords: NMR, fructus rhodomyrti, quinone, structure elucidation, cytotoxic activity.
Fructus rhodomyrti is the seed of Rhodomyrtus tomentosa (Ari.) Hassk., which is a traditional Chinese medicine
material with antihepatitis property used in South China [1]. The flavonoid extracts from fructus rhodomyrti have antiradical
and antioxidant activity as reported in [2]. It has been revealed that fructus rhodomyrti contains flavonoid glycosides, phenols,
amino acids, organic acids, and other chemical constituents [1, 3], but there are few reports on the detailed chemical ingredients
of fructus rhodomyrti. A systemic research of the components from fructus rhodomyrti has been carried out by us. Two new
compounds, compound 1 and 2, were isolated from the ethanol extracts of this traditional Chinese medicine. In the in vitro
cytotoxic tests, compounds 1 and 2 showed cytotoxicity to KB and KBv200 cell lines with IC
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