0.5桃金娘中两种醌类化合物结构鉴定2011.pdfVIP

Chemistry of Natural Compounds, Vol. 47, No. 4, September, 2011 [Russian original No. 4, July–August, 2011] STRUCTURE ELUCIDATION AND NMR ASSIGNMENTS FOR TWO NEW QUINONES FROM FRUCTUS RHODOMYRTI OF Rhodomyrtus tomentosa 1,2 3 1* Tao Chen, Chuguo Yu, and Bolun Yang UDC 547.972 Two new quinones, 1,4,7-trihydroxy-2-methoxy-6-methylanthracene-9,10-dione (1) and compound 2, were isolated from fructus rhodomyrti of Rhodomyrtus tomentosa (Ari.) Hassk., which was collected from Guangdong Province. The structures were elucidated by 1D, 2D NMR, and HR-EI-MS spectroscopy methods. The cytotoxic activities of two compounds in vitro were tested. Compound 1 showed cytotoxicity against KB and KBv200 cell lines with IC50 of 17.1 and 19.5 g/mL, and compound 2 with IC50 of 18.1 and 25.4 g/mL, respectively. Keywords: NMR, fructus rhodomyrti, quinone, structure elucidation, cytotoxic activity. Fructus rhodomyrti is the seed of Rhodomyrtus tomentosa (Ari.) Hassk., which is a traditional Chinese medicine material with antihepatitis property used in South China [1]. The flavonoid extracts from fructus rhodomyrti have antiradical and antioxidant activity as reported in [2]. It has been revealed that fructus rhodomyrti contains flavonoid glycosides, phenols, amino acids, organic acids, and other chemical constituents [1, 3], but there are few reports on the detailed chemical ingredients of fructus rhodomyrti. A systemic research of the components from fructus rhodomyrti has been carried out by us. Two new compounds, compound 1 and 2, were isolated from the ethanol extracts of this traditional Chinese medicine. In the in vitro cytotoxic tests, compounds 1 and 2 showed cytotoxicity to KB and KBv200 cell lines with IC