糖类化合物的化学修饰和其生物活性的研究进展.pdfVIP

R EVIEWS REVIEW ON THE CHEMICAL MODIFICATION OF THE SACCHA RIDES AND THE BIOACTIVITY CHANGES OF MODIFFIERS 袁华茂1,2 宋金明1 1 ( 266071) 2 ( 100039) Q53 A 1000- 3096( 2003) 03- 0027- 05 ( endotoxic shock) Jac ues [3] q , , 2NH2 , 2 D6 NH2 1, 3, 4O , , , , , , , , 2, 3, 4N, O 1 2, 3N, O42 12 , A , DNA , Nobuhiro[4] , C1 , C2 NH2 , , C1 NH2 C6 [ 1] , , C2 C3 , DNA 2+ , , , Cu , , [2] 1. 2 蒽基塔罗吡喃糖的修饰 , ( doxorubicin) DOX ( daunorubicin) DNR 1 单糖的化学修饰 1. 1 氨基葡萄糖的修饰 A , : , 1975 , A , Email: uanhuamao@ ms. qdio. ac. cn , : : Marine Sciences/Vol. 27, No. 3/ 2003 27 R EVIEWS H, F I, 2F3, 4 Yasushi[5~ 7] L12 10DOX, DNR 3NH2 OH, OMe, , DOX, DNR 3OH , 5CH3 ATP NH2 CF3, CF3 CH3 , , , , 5 mol/ L 1. 3 D核糖核苷的修饰 , 3 ,