肿瘤浸润性树突状细胞地研究进展.pdfVIP

5 中国癌症杂志6 2005 15 2 CH INA ONCOLOGY 2005 Vol. 15 No. 2 185 肿瘤浸润性树突状细胞的研究进展 综述 审校 , , 610041 [ ] ( DCs) , T , (T IDCs), T IDC , DC, DC , [ ] ; ; : R730. 51 : A : 1007-3639( 2005) 02-0185-04 Advances in research of tum or infiltrating dentritic cells WANG Qi, LIN Ping (D ivision of Experi- m ental Oncology, ey Laboratory of Biotherapy of H uman D iseases, M inistry of Education, Sichuan Uni- versity West ChinaH osp ital, Chengdu Sichuan 610041 , China) [Ab stract] A s antig n-pr s nting c lls, DC s ar th most pot n t and un iqu , th y can stmi u lat th prmi itiv T c lls. Th y play a m ajor rol in in itiating th mi m un r spons . Tum or in filtrating d ndritic c lls (T IDC s) can r fl ct th antitumor mi mun capab ility of th host. Th d ns ity ofT IDC p rhaps is associat d w ith th prognos is in som canc rs. Th d isab l m nt of T IDCS is partly du to th ph notyp th y hav . P rhaps it is th mi munosuppr ssiv factors s cr t d by tumor c lls that hav chang d th ir ph notyp . Th studi s about T IDCs provid th basis for DC-m diat d antitum or mi - mun th rapy, and sugg st th us of DC to tr at tum ors th rough diff r nt approach s. [K ey w ords] tum or infiltrating d ndritic c lls; tumor prognosis; m ol cular xpr ssion of DC + + 1973 , S t inman Cohn CD 1a S-100 T IDC DC, ( DCs) [ 1] , , , DCDC s T IDC , T , DC , , , DC , DC , , , DC ,