活性氧在多能干细胞中的作用.pdfVIP

· 188 · 中国病理生理杂志 ChineseJournalofPathophysiology 2014，30(1)：188·192 [文章编号] 1000-4718(2014)01—0188—05 活性氧在多能干细胞中的作用水 徐 洁， 刘俊许， 康雪玲， 蒋 丽， 周忠伟， 陈思锋，孟 丹 (复旦大学上海医学院生理与病理生理学系，上海200032) Rolesofreactiveoxygenspeciesinpluripotentstem cellfunctions XUJie，LIUJun-XH，KANGXue-ling，JIANGLi， ZHOU Zhong—wei，CHEN Si—feng，MENG Dan (DepartmentofPhysiologyandPathophysoilogy，FudanUniversityShanghaiMedicalCollege， Shanghai200032，China．E-mail：dmeng@fudan．edu．cn) [ABSTRACT] Pluripotentstemcellsarecharacterizedbythepropertiesofse~renewalandtheabilitytodifferenti— ateintomultiplecelltypes．Reactiveoxygenspecies(ROS)arehis【hlyreactivemetabolites．HighlevelsofROSaretoxic andinvolvedinstem cellsenescenceandapoptosis．However，regulationofROShasanimportantrole inmaintaining “ stemness”anddifferentiationofthestem cells．TheroleofROSinthestem cellsvariesamongdifferentstem celltypes． NADPHoxidaseisoneofthemajorsourcesofROSinstemcells．ExcessiveamountsofROS8tieproducedinvariouspatho— physiologicalstatessuch85atheroscleresis，heartfailure，hypertension，diabetes，andaging．Inducedpluripetentstem cellshavethepotentialtobeusedinmodelingofROS—associateddiseases．Understna dingthemolecularmechanismshow ROSregulatethefunctionsofstem cellswillgreatlyenhancetheirtranslational applications．Inthisreview，wesummarize therecentprogressregardingtherolesofROSinregulatingthefunctionsofembryonicandinducedpluripotentstem cells． [关键词] 诱导性多能干细胞；胚胎干细胞；活性氧 [KEYWORDS] Inducedpluripotentstemcells；Embryonicstemceils；Reactiveoxygenspecies [中图分类号] Q25 [文献标志码] A doi：10．3969／j．issn．1000—4718．2014．01．033 多能干细胞是具有 自我更新能力和能向体内多 化潜能的多能干细胞 (pluripotentstem cells)和增 种细胞分化的一类细胞群体。活性氧(reactiveoxy- 殖、分化能力有限的成体干细胞 (adultstemcells)。 gen