血管内皮细胞生长因子受体和其抑制剂的肿瘤治疗研究.pdfVIP

# 1566 # 2007 10 13 20 Medical Recapitulate, Oct ber 2007,V l. 13, N . 20 王英娟, 赵玲娣, 司玉玲 ( , 300140) : R73 :A : 1006-2084( 2007) 20- 1566-03 : 新生血管为肿瘤组织提供氧和营养物质, 在肿瘤的生长与转移过程中起重要作用肿 , 瘤血管的 成是多种细胞因子综合作用的结果, 在这些细胞因子中研究最多的是血管内皮细胞生 , 长因子血管内皮细胞生长因子与其受体结合后通过酪氨酸激酶途径引起细胞的增殖及新生血 管 成抑制血管内皮细胞生长因子介导的途径可使肿瘤缩小, 目前抗血管内皮细胞生长因子治 , 疗已成为靶向治疗的热点 : 血管生成; 血管内皮生长因子; 血管内皮生长因子受体 Study of VEGFR and its Inhibitors in the Treatment of Tumors WANG Ying-j uan, ZHAO Ling-di, SI , VEGF-A Yu-ling . ( Department of Tumor andHemotology, Forth entral Hosp ital of Tianj in, Tianj in 300140, hina) Abstract:The new vascular pr vides xygen and nutrients f r the tum rs and plays an imp rtant r le in its gr wth and metastasis.The f rmati n f vascular in tum rs is the result f interacti ns f many cyt kines, am ng , which vascular epithelial gr wth fact r is the ne studted m st .Vascular epithelial gr wth fact r binding with its [3] recept r leads t cell pr liferati n and new vascular f rmati n by tyr sine kinase pathway. The inhibiti n f this pathway may result in the shrinkage f tum r. At present, anti-VEGFR therapy is bec ming the h t sp t f its VEGFR targeted therapy. Key words: Angi genesis; Vascular end thelial gr wth fact r; Vascular end thelial gr wth fact r recept r , , VEGFR VEGF , , , , , , , ( vascular end thelial gr wth fac- VEGF