阿拓莫兰联合促肝细胞生长素对严重外伤性肝破裂术后肝功能保护作用.docVIP

阿拓莫兰联合促肝细胞生长素对严重外伤性肝破裂术后肝功能的保护作用 　　作者：白雪峰,王平瑜,张俊杰,王保卫　　作者单位：河南驻马店，解放军第159医院普外科 　　【摘要】目的总结评价阿拓莫兰联合促肝细胞生长素对严重外伤性肝破裂术后肝功能的保护作用及临床治疗效果。方法 采用随机平行对照试验设计，将60例严重外伤性肝破裂手术患者分为两组，治疗组术后辅以阿拓莫兰联合促肝细胞生长素护肝治疗，另一组为对照组。结果 治疗组术后1、3、7天肝功能各项指标包括血清丙氨酸氨基转移酶(ALT)、天门冬氨酸氨基转移酶(AST)、血清总胆红素(TBIL)恢复明显优于对照组(P0.05)。白蛋白(ALB)术后1天高于对照组(P0.05)。两组间术后病死率、并发症的发生率差异无显著性(P0.05)。治疗组术后平均住院时间短于对照组，但差异无显著性(P0.05)。结论 阿拓莫兰联合促肝细胞生长素对严重外伤性肝破裂手术患者术后肝功能损害有治疗作用，有一定的临床使用价值。 　　【关键词】 阿拓莫兰;促肝细胞生长素;严重外伤性肝破裂;肝功能 　　Protective effect of liver function of severe traumatic rupture in liver with glutathione and pHGF 　　BAI Xue-feng,WANG Ping-yu,ZHANG Jun-jie,et al. Department of General Surgery,159 Hospital of PLA, Zhumadian 463000,China 　　[Abstract] Objective To evaluate the protection of reduced glutathione and clinical therapeutic efficacy in patients with partial hepatectomy accompany with blocking fossa transversalis hepatic blood flow.Methods A randomized controlled trial of parallel design,60 cases of patients with partially hepatectomized postoperative supplemented by reduced glutathione and a control group.Results The index of the liver function during postoperative 1,3,7 d in treatment group including serum glutamate-pyruvate transaminase(ALT), aspartic acid transaminase(AST), and serum totalbilirubin(TBIL),was better than the control group(P0.05). Albumen(ALB) on postoperative 1 d was higher than the control group(P0.05).The fatality and the incidence rate of complication among postoperative cases were no significant difference(P0.05).Postoperative average stay of the treatment group was shorter than the control group, but had no significant(P0.05).Conclusion The reduced glutathione was a genuine therapeutic action in the development of postoperative liver function damage restoration, on the condition that patients with partially hepatectomized accompany with blocking fossa transversalis hepatic blood flow. It could have a certain degree of clinical use value. 　　[Key words] A glutathione; PHGF;