阿苯达唑联合手术和单纯手术治疗肝细粒棘球蚴病的系统评价.pdfVIP

摘 要 阿苯达唑联合手术和单纯手术治疗肝细粒棘球 蚴病的系统评价 研究生：周成明 导师：温 浩 教授 摘 要 目的：系统评价阿苯达唑联合手术和单纯手术治疗肝细粒棘球蚴病（HCE ）的 疗效。方法：通过计算机检索和手工检索，全面收集相关的随机对照试验，按Cochrane 协作网推荐的方法进行分析。结果：仅3个试验符合纳入标准，其方法学质量评价均 为“B ”级。3个研究比较了阿苯达唑联合手术和单纯手术治疗HCE 的疗效，结果显 示两组的有效率差异有统计学意义[RR 1.73, 95%CI (1.33, 2.25), P0.0001], 并且阿苯 达唑术前用药3个月较术前用药1个月效果好[RR 1.38, 95%CI (1.17, 1.64), P=0.0002]， 但是两组在术后复发率方面的比较无明确差异[RR 0.14, 95%CI (0.01, 2.65), P=0.19]。 结论：阿苯达唑联合手术治疗肝细粒棘球蚴病的有效率明显好于单纯手术治疗，并 且术前用药3个月较术前用药1个月更有效，但两组的术后复发率无明确差异。由于 本系统评价纳入试验数和病例数较少，测量指标不全面，因此会影响到上述结论的 强度。要确定阿苯达唑联合手术和单纯手术治疗肝细粒棘球蚴病的效果，尚需开展 更多高质量试验。 关键词：阿苯达唑；手术治疗；肝细粒棘球蚴病；随机对照试验；系统评价 —1— 新疆医科大学医学硕士学位论文 Comparison between albendazole combined with surgery and surgery alone for the treatment of hepatic cystic echinococcosis: a systematic review Postgraduate: Zhou Chengming Supervisor: Prof. Wen Hao Abstract Objective:To evaluate the efficacy and safety of albendazole (ABZ) combined with surgery versus surgery alone in the treatment of HCE. Methods:All relevant randomised controlled trials were searched by electronic and handsearching. Studies were analyzed according to the methods recommended by The Cochrane Collabration. Results:Three trials meet the inclusion criteria. They show that ABZ combined with surgery is more effective than surgery alone in the treatment of HCE [RR 1.73, 95%CI (1.33, 2.25), P0.0001].as well, 3-month preoperative therapy is superior to 1 month preoperative therapy [RR 1.38, 95%CI (1.17, 1.64), P=0.0002]. In addition, there is no difference in the recurrence rate between the two groups of