免疫比浊法检测大肠癌和胃癌患者血清β2.docVIP

免疫比浊法检测大肠癌和胃癌患者血清β2微球蛋白的临床意义 免疫比浊法检测大肠癌和胃癌患者血清Β2微球蛋白的临床意义 作者：熊兵红 程勇　　 作者单位：400016 重庆医科大学附属第一医院胃肠外科 【摘要】 目的 探讨大肠癌和胃癌患者血清Β2微球蛋白(Β2microglobulin，Β2MG)含量变化及其临床意义。方法 用免疫比浊法检测30例大肠癌和30例胃癌以及30例正常健康人血清Β2MG含量；动态检测大肠癌和胃癌手术前后Β2MG含量变化。结果 大肠癌组和胃癌组血清中Β2MG含量均明显高于健康对照组(P0.01)；大肠癌和胃癌术前血清Β2MG含量增高者，术后含量均明显降低(P0.01)。结论 检测血清Β2MG含量变化在大肠癌和胃癌辅助诊断以及疗效判断方面具有重要临床意义。 【关键词】 Β2微球蛋白 大肠肿瘤 胃肿瘤 免疫比浊法 Clinical significance of immunoturbidimetric assay in detecting serum Β2microglobulin (Β2MG) in patients with colon cancer and gastric cancer XIONG Binghong, CHENG Yong. Department of Gastrointestinal Surgery, First Affiliated Hospital, Chongqing University of Medical Sciences, Chongqing 400016, China 【Abstract】 Objective To observe level change of serum Β2microglobulin (Β2MG) in patients with colon cancer and gastric cancer and discuss clinical significance of immunoturbidimetric assay. Methods The content of serum Β2MG was detected in 30 patients with colon cancer, 30 with gastric cancer and 30 normal persons by means of immunoturbidimetric assay. Dynamic detection of content of Β2MG was done via automated chemistry analyser before and after operation for colon cancer and gastric cancer. Results The level of serum Β2MG in patients with colon cancer and gastric cancer was much higher than that in normal persons (P 0.05). Preoperative high level of serum Β2MG in patients with colon cancer and gastric cancer were reduced dramatically after operation (P0.01). Conclusion Immunoturbidimetric assay detecting level changes of serum Β2MG plays an important role in assisting diagnosis and judgment of therapeutic effects for colon cancer and gastric cancer. 【Key words】 Β2microglobulin; Colon cancer; Gastric cancer; Immunoturbidimetric assay 大肠癌和胃癌都是目前严重威胁人们健康的消化道肿瘤，确诊时多为中晚期。如何判断手术效果和评价预后仍是目前面临的一个问题。Β2微球蛋白(Β2microglobulin，Β2MG)是人类白细胞抗原(human leukocyte antigen,HLA)I类分子编码的轻链即Β链部分。它是诊断早期肾功能不全的一项重要指标。研究表明，肿瘤的发生发展与Β2MG的关系密切。