上皮钙粘附蛋白在胃癌及其淋巴结组织中表达的生物学意义.pdfVIP

1246 2007 20 11 　J M ed T h eor Prac V ol.20, N o.11, N ov 2007 ○ ○ 上皮钙粘附蛋白在胃癌及其淋巴结 组织中表达的生物学意义 陈　忠　叶智勇　 丁　斌 　366000 　目的:(E-cadherin, E-cad)。方法:SP 80 E-cad 。结果:80 E-cad 55.00%。E-cad L auren 、、、、(P0.05), 、、。E-cad 35.48%32.26 %。E-cad (R = 0.497 8, P0.05 )。结论:E-cad 、。 　　　E-　 :R7 35.2 　:A 　:100 1-7585(2007)11-1246-04 Biological Implication of the Expression of E-cadherin in Gastric Carcinoma and Its Lymph Node Metastasis CHEN Zhong, YE Zhiyong, DING Bin.D ep ar tm en t of P a tho logy , Yongan M un icip a l H osp ita l, Yong an City ,F u- j ian P rov ince 366000 AB TRACT Objective:T o investig ate the asso ciatio ns o the ex pression lev el o E-cadherin w ith the clinico pa tho log ical ea tur es o gastric ca rcinomas.Methods:T he e xpression level o E-cadhe rin in 80 cases o gastric carcinoma s a nd their me ta staic lymph node tissues w ere examined by immunohistochemical assay s.Results:T he ex pression rate o E-cadherin in 80 cases o g astric carcinoma s w as 55.00%.T he ex pression level o E-cadhe rin w as positively co rrelated w ith the Lauren classi ication, the deg ree o histo lo gical di er entiatio n, the clinical stage, the depth o invasion, lymph node me ta sta sis and distant metastasis (P0.05), but w as no t co rrelated to patient s sex, age and tumor size.T he expres- sio n rates o E-cadherin in me tasta tic g astric car cino ma o primary le sions and ly mph nodes metastasis w ere 35.48% and 32.26 %, respectiv ely .F urthe rmo re, E-cadherin ex pression in metastatic ga st ric ca rcinoma w as signi icantly cor re- lated w ith primary lesions and ly mph nodes metastasis (P earson cor rela tion co e icient R=0.4978,P0.05).Conclu- sion:T he ex pression level