急性脑梗死患者血小板表达PECAM1P选择素的改变及奥扎格雷钠对其影响.pdfVIP

塞瀣墓笠急性膻攮殛盅鲞壶41扳麦达匹堡垒M：!，里选捶塞煎熬变丛墨主L登萱鲴盟甚丝瞳簋12趣 ·1609· 急性脑梗死患者血小板表达PECAM一1、P选择素的改变及 奥扎格雷钠对其影响 朱海英冷振璞1 (济南市第四人民医院神经内科，山东 济南250031) [摘要] 死患者随机分常规治疗组和奥扎格雷钠治疗组，采用全血流式细胞术检测发病48h(治疗前)和治疗后7、14 平。并与30例健康对照组比较。结果脑梗死患者发病48 治疗组缓慢，P选择素下降较常规组快。结论奥扎格雷钠能促进脑梗死患者血小板P选择素的下降，减缓PECAM．1的下降。 (关键词]脑梗死；PECAM一1；P选择素；血小板；血栓烷合成酶抑制剂 (中圈分类号】R743．32(文献标识码】A 【文章编号】1005-9202(2006112-1609．03 in with with of of acutecerebralinfarctionandinterferencedSodium ChangesexpressionplateletPECAM一1，P-selecttnpatients Ozagrel ZHU Zhen-Pu． Hai-Ying，LENG of Fourth in NeurologyMedicine，the Jinan，JJnan250031，Shandong，China Department People’SHospital with Toobservethe of in acutecerebral 【Abstract】Objectlve changesplateletPECAM一1，P-selectinpatients of andtlleeffectSodium onthese 68ACI were dividedintocommon and Ozagrel changes．Methodspatientsrandomly therapygroupOzagrel weredetectedthewholebloodflow 48hbeforetreatmentand after therapygroup，andplateletPECAM．1，P．selectin by cytometry 7，14days werecontrastedwitllthoseofnormalcontrols．ResultsPlateletsPECAM．1andP．selectinwithin48hoursafterstrokeonset therapy．which increased thelevelsofPECAM-1declinedmore thelevelofP．selectindeclinedmore significantly，afterOzagreltherapy slowly，while faster。 thanthose couldaccelcratethedeclineofP．selecfin anddeceleratethede． ofcommon Ozagreltreatment t11erapy．Conclusions expression clineofPECAM．1 inACI expressionpatients． Ce