抗原处理相关转运体1和主要组织相容性复合体Ⅰ类分子在尖锐湿疣皮损中的表达及相互关系探讨.pdfVIP

堕鏖廛壁型苤查2QQ!生!垒鲞箜至塑』堡!i里望!墅型!LE!b婴!盟至QQ墨：y!!：!垒：盥!：2 85 论著 抗原处理相关转运体1和主要组织相容性复合体一l 类分子在尖锐湿疣皮损中的表达及相互关系探讨 张杏平．陈兴平 (华中科技大学同济医学院附属同济医院皮肤性病科，湖北武汉430030) I类分子表达降低，MHC—I类抗原提呈途径缺陷，这在人乳头瘤病毒逃逸机体免疫监视的过程中可能发挥着重要的作用。 陕键词】尖锐湿疣；抗原处理相关转运体1；主要组织相容性复合体一I类；抗原提呈 f中图分类号1R752．53 f文献标识码]A [文章编号11000—4963(2005)02—0085—03 andcorrelationofTAPlandMHC—Imoleculesin acuminatumlesions Expression condyloma ZHANG Xing—ping，CHENXing—ping Medical Scienceand (DepartmentofDermatovenereology,TongfiHospital，TongjiCollege，HuazhongUniversityof Wuhan 430030,China) ifthereis ofMHC-I the ofTAPl 【Abstract】Objective：To explore deficiency antigenpresentingbystudyingexpression in acuminatum TAPl MHC—1wasdetectedimmuno— andMHC—Icondyloma fCAllesions．Methods：Theof and by expression in30casesof CAand10 ofnormal ofTAPlandMHC—Ide— histochemistry specimens prepuce．Results：Theexpression creased inCAlesions withthenormalcontr01．A correlationbetweenthe ofTAPl significantly compared positive expression andMHC-1wasobservedinCAlesions．Conclusions：TheofMHC—I causedthe deficiency antigenpresentingby depressed TAPl an role from of andMHC—I inthe ofHPV expression mightplay important process escaping 【Keywords】condylomaacuminatum；TAPl；MHC—I；antigenpresenting 阻Clin acuminatum，CA)的发病机制 尖锐湿疣(condyloma 自我院泌尿外科手术切除的正常男性包皮组织