食管鳞癌患者手术前后外周血T细胞亚群与NKNKT细胞检测的临床意义.pdfVIP

现代肿瘤医学 2010年 6月 第 18卷第 6期 一 k isassociatedwiththebasal—likephenotypeinbreastcarci— therapy[J]．NEnglJMed，2005，353：172—187． nomasofAfricanwomen[J]．APMIS，2008，l16：515—525． [12] BhargavaR，GeraldWL，LiAR，eta1．EGFRgeneamplificationin [10] Pna W ，MillerVA．Epidemr al growth factorreceptormutations， breastcancer：correlation wiht epidermal growth factorreceptor smallmolecuhkinaseinhibitorsandnon—smallcelllungcane— mRNA na dprotein expressionnad HER2 statusnadabsenceof er：currentknowledgeandfuturedirections[J]．JClinOncol， EGFR—activatingmutations[J]．MadPathol，2005，18：1027— 2005，23：2556—2568． 1033． (编校 ：李鹏超) KrauseDS．VanERenRA，Tyrosinekinasesastargetsforca$1cer 食管鳞癌患者手术前后外周血 T细胞亚群与NK、NKT细胞检测的临 床意义 洪超群 ，陈炯玉 ，杨卫平 ，吴 晓 ，游颜杰 ClinicalsignificanceofdetectingthelevelsofT—lymphocytesubsets，NKandNKTcells inperipheralbloodofpatientswithesophagealsquamouscellcarcinomabeforeandafter operation HONGChao—qun，CHENJiong—yu。，YANGWei—ping，WUXiao，YOUYan—jie CancerHospitalofShantouUniversityMedicalCollege，GuangdongShantou515041，China；MedicalCollegeof ShantouUniversity， GuangdongShantou51540 1，China ． A【bstract】 0bjective：ToanalyzethecharacteristicsandclinicalsignificanceofTlymphocytesubgroups，NKand NKTceilsinperipheralbloodofpatientswithesophagealsquamouscellcarcinoma(ESCC)．Methods：Tlymphocyte subgroupsNKandNKTcellsinperipheralbloodof78patients tllESCCweremeasuredbyfloweytometryfFCM)． Results：Beforeoperation，thelevelofNKTcellswassignificantlydecreasedinhighdifferentiationgroupthanthatin moderate—lowdefferentiationrgoup(P0．05)．Forpatients14daysafteroperation，thelevelofCD8 lymphocyte cellswasdecreased(P0．01)andCD4 ／CD8 ratiowasincreased(P0．01)，comparedwitllhtatbeforeopera· tion．Meantime，thelevelsofNKcellsandNKTcellswerealsodecreasedmarkedly(P0．01)．Conclusion：Col— lapsedimmunologicalfunctionscouldbeimproved