雌激素和动脉粥样硬化.pdfVIP

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·1124 · 医学综 述 2012 年 4 月 第 18 卷第 8 期 Medical Recapitulate, Apr. 20 12 , V ol . 18 , No. 8 kinase B gamma ( PKB gamma/ Akt3) in postnatal brain develop- regulation of endogenous IL-1beta and suppressor of cytokine sig- ment but not in glucose homeostasis [ J] . Development, 2005, 132 nalling-1 in mouse pancreatic beta cells [ J] . Cell Signal, 20 10, 22 ( 13) : 2943-2954. ( 5) : 79 1-800. [ 17] Icyuz M, Bryant SM, Fortinberry HK, et al. A denovirus infection ac- [ 24] Harbeck MC, Loui e DC, Howland J, et al. Expression of insulin re- tivates akt1 and induces cell proliferation in pancreatic islets1 [ J] . ceptor mRNA and insulin receptor substrate 1 in pancreatic islet Transplantation, 2009, 87 ( 6) : 82 1-824 . beta-cells[ J] . Diabetes, 1996, 45 ( 6) : 711-7 17 . [ 18] Liu Y , Tanabe K, Baronnier D, et al. Conditional ablation of Gsk-3 β [ 25] Assmann A , Ueki K, Winnay JN , et al. Glucose effects on beta- in islet beta cells results in expanded mass and resistance to fat c ell growth and survival require activation of insulin receptors feeding-induced diabetes in mice [ J] . Diabetologia, 2010, 53 ( 12) : and insulin receptor substrate 2 [ J] . Mol Cell Biol, 20 09 , 29 2600-26 10. ( 1 1) : 32 19 -3 228 . [ 19] Velazquez-Garcia S, Valle S, Rosa TC, et al. Activation of protein [ 26] Niessen M. On the role of IRS2 in the regulation of functional beta- kinase C- ζin pancreatic β-cells in vivo improves glucose tolerance cell mass [ J] . A rch Physiol Biochem, 2006 , 112( 2) : 65-73. and induces β-cell expansion via mTOR activation[ J] . Diabetes, [

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