经皮冠脉介入治疗对左心室收缩功能正常的不稳定型心绞痛患者BNP水平的影响.docVIP

经皮冠脉介入治疗对左心室收缩功能正常的不稳定型心绞痛患者BNP水平的影响 　　作者：王娜 胡宾 秦兰萍 韩丽军 杜凤和 作者单位：100050 北京市，首都医科大学附属北京天坛医院心内科(王娜、韩丽军、杜凤和);首都医科大学附属北京安贞医院心内科(胡宾)，流行病研究室(秦兰萍) 　　【摘要】 血清脑钠素(BNP)水平是判断心力衰竭严重程度和预后的重要指标。国外研究表明,BNP在各种类型的急性冠脉综合征(ACS)患者中均可升高[1],ACS患者常伴左心室收缩功能异常，目前关于左心室收缩功能正常的ACS患者BNP水平变化特征研究较少。 　　【关键词】 利钠肽;心绞痛，不稳定型;经皮冠状动脉介入治疗 　　Effect of percutaneous coronary intervention on the levels of Bype natriuretic peptide in patients with unstable angina pectoris WANG Na*,HU Bin, QIN Lanping,et al.*Department of Cardiology, Beijing Tiantan Hospital Affiliated to Capital Medical University, Beijing 100050, China 　　【Abstract】 Objective To investigate the relationship between Btype natriuretic peptide (BNP) levels and extent of ischemia in patients with unstable angina pectoris and normal left ventricular function,and the response to percutaneous coronary intervention (PCI).Methods One hundred and three patients with unstable angina pectoris and normal left ventricular function (identified by echocardiography) underwent PCI were divided into three groups according to the results of coronary angiography: one vessel pathological change group (n=23), two vessels group (n=43), and three vessels group (n=37).The BNP levels were detected at baseline, 3 days and 90 days after PCI.Results There were significant differences in the BNP levels before PCI among the three groups(P0.05);3d after PCI the BNP levels were significantly increased,as compared with those before PCI P0.05),however, 30d after PCI the BNP levels were significantly decreased,as compared with those before PCI (P0.05).Conclusion The increase of BNP levels is closely related with vessel number of pathological change in patients with coronary heart disease (CHD),which can be used as an important index in CHD. 　　【Key words】 brain natriuretic peptide;angina pectoris, unstable; percutaneous coronary intervention 　　血清脑钠素(BNP)水平是判断心力衰竭严重程度和预后的重要指标。国外研究表明,BNP在各种类型的急性冠脉综合征(ACS)患者中均可升高[1],ACS患者常伴左心室收缩功能异常，目前关于左心室收缩功能正常的ACS患者BNP水平