桃核承气汤对肾小球硬化大鼠肾功能的改善作用 Effects of Taohechengqi Decoction on Renal Function in Rat Model of Glomerulosclerosis.pdfVIP

中国中医急症2012年3月第2l卷第3期 ·实验研究· 桃核承气汤对肾小球硬化大鼠肾功能的改善作用木 赵艳明1纪宝华2符强2A (1．黑龙江省公安厅安康医院，黑龙江哈尔滨150078；2．黑龙江中医药大学，黑龙江哈尔滨 150040) 中图分类号：R285．5文献标志码：A文章编号：1004—745X(2012)03—0390-02 【摘要】目的观察桃核承气汤对肾小球硬化大鼠肾功能的影响。方法采用5／6肾切除法建立肾小球硬化大 鼠模型，4周后按血肌酐水平将造模大鼠分为模型组，高、低剂量组和福辛普利(蒙诺)组，连续观察给药后各 组大鼠肾功能变化情况。结果模型组大鼠肾功能持续下降，血肌酐、尿素氮持续升高，各治疗组与模型组比 较有不同程度下降。结论桃核承气汤可改善模型大鼠肾功能，延缓。肾小球硬化进展。 【关键词】 桃核承气汤 肾小球硬化 肾功能 Effectsof DecoctiononRenalFunctioninRatModdofGlomerulosclerosisZHA0Yah— Taohechengqi Public mi，lgj，∥Bao—hua2，FU(?i衄92．1Ankang ofHeilon∥iangSecuh@Agency，Heilon百iang，Harbin， Hospital 150078；2 tteiZonviongUnwem妙旷ChineseMedicine，Heilon巧iang，Harbin，150040 theeffectof Decoctionontherenalfunctioninratmodelof 【Abstract】Objective：Tostudy Taohechengqi ratmodelof wasestablishedfrom5／6 weeks glomerulosclerosis．Methods：The glomerulosclerosis nephrectomy．4 ratswere divided lowdose dose andthefos- later，these intothemodel randomly group，the group，thehigh group Decotionand was administeredfor8 andScrin inoprilgroup．AfterTaohechengqi fosinoprilorally weeks，BUN these were withnormal BUNandScrinthemodel groups determined．Results：As group。the compared group were increased．Thereweresomeobviousreducesinthesetreatmentandmodel about significantly groups group those DecoctionCan thetherenalfunctionand fibrosisde- indices．Conclusion：Toohechengqiimprove suppress ofrats． velopment function Decoction；Renalfibrosis；Renal 【Ke