《Assessment of XAF1 as A Biomarker to Differentiate Hepatocellular Carcinoma from Nonneoplastic Liver Tissues》.pdfVIP

ChjnjC0ncerRes 2D工 wwW．springe州nk．com 24}3)：201之06，2012 XAFlasA toDifferentiate Assessmentof Biomarker Carcinomafrom LiVerTissues Nonneoplastic YingLinl，We|L l|nstitute Qnd ofB’o|ogicd|sciencesB|otechno|ogy．DonghuQUniversity，shdnghoi201620．Chin0 2 B}omedicine Center KeyLoborotory时SystemsIM|n|stryofEaucQtIon}．shonghoiforSystems8iomedic’ne， ShQnghQiJiQotongUniversity，ShonghQi200240，Chino 10．1007，s11670-012—0201-0 @ChineseAnti-CancerAssociationand BerIin 2012 Springe卜Verlag Heide№erg A8STRACT ×IAP．associatedfactor1 hasbeenshowntoberelatedwith in Objective： (XAFl)expression apoptosis correIationof×AFl withHCCtumor hasnotbeen hepatoce||uIarcarcinoma(HCC)．However，the expression grade assessed．x{AP—associatedan inducerinhumanHCC．Theaimofthis ；ntensiveIv factor一1(×AFl)isimportantapoptosis istodeterminethecorreIationbetween×AFlandHCC studV expressionhistopathoIogicalgrades． Methods：ThemRNAleveIsof朋F工in24 were reaI—time pairedHCC—nOnneoplasticspec．r_nensquantifiedby reverse IeveIsofXAFlin110 HCC—noncancertissueswere transcriptionPCR(RT—PCR)．Protein paired investigatedby onatissue betweenXAF工mRNAleveIsor immunostainingspecimens microarray(TMA)．CorreIations p∞tein and featureswereassessedsta