_紫草素复方的药代动力学研究_庞志功.pdf

2 2 4 Vol . 2 2 No . 4 2 0 0 1 8 Aug . 2 0 0 1 JOURNAL OF XIpAN MEDICAL UNIVERSIT Y B-紫草素复方的药代动力学研究 庞志功, 汪宝琪, 李海峰* ( , 7 1006 1) : 目的 对B-紫草素在方剂中药代动力学进行研究方法 用过氧化氢氧化B-紫草素中 含羟基的反应与鲁米诺- 过氧化氢- 钴离子化学发光反应相偶合进行测定结果 用实用药动学 计算程序3P87 处理数据得到系列药动学参数结论 B-紫草素在复方中有更大的药效作用 : B-紫草素; 复方药动学; 化学发光 : R932111; R911 : A : 0258-0659( 2001) 04-0319-02 Study on the compound pharmacokinetics of B-shikoninMPang Zhigong , Wang B ao- q i , L i H aif eng MDepartment of Pharma y, Xi. an Jiaotong University, Xi. an 710061, China ABSTRACT:Objective To study the pharma okineti s of B-shikonin in the pres ription. Methods Determinating the Ox idation of hy droxyl group in B-shikonin by H O w as oupled w ith the Lumi- 2 2 2+ nol-H O-Co hemi lumines ent rea tion. Results We obtained a series of pharma okineti s pa- 2 2 rameters by the fun tional pharma okineti s program 3P87. Conclusion B-shikonin in ompound pharma y has more effe t . EYWORDS:B-shikonin; ompound pharma okineti s; hemilumines en e B- ( B-shikonin ) ( Sinkiang , Gromwell Root) ) ( , [ 1, 2] , ) , 112 , 11211 血浆样品的前处理 , B-24 h ( 40 ) 5 g; ) 5 g B-, 2 g215 g215 g5 g , 2 , 30 mL , 120 mg, 950 mL#L- 1 , B-