人参白虎汤对糖尿病大鼠周围神经病变的影响.pdfVIP

人参研究 年第 期 6 GINSENG RESEARCH 2011 1 人参白虎汤对糖尿病大鼠周围神经病变的影响 赵保胜 桂海水 朱寅荻 徐暾海* 北京中医药大学·北京北京· ( 100029) 摘 要： 目的：探讨人参白虎汤对实验性糖尿病大鼠周围神经病变的影响。 方法：四氧嘧啶尾静脉注射 复制高血糖大鼠模型，以大鼠机械刺激痛阈、大鼠坐骨神经传导速度与坐骨神经病理形态学改 变为主要指标，观察人参白虎汤对糖尿病大鼠周围神经病变的影响。 结果：人参白虎汤可明显 提高糖尿病大鼠痛阈值(P0.05 或P0.01) ，提高坐骨神经传导速度P0.01) ，明显地改善高血糖 引起的神经纤维髓鞘变性(P0.05 或P0.01) ，具有一定的抗糖尿病周围神经病变的作用。 关键词：人参白虎汤；糖尿病；周围神经病变 Pharmacodynamic study of Renshenbaihu Tang on the treatment of diabetic peripheral neuropathy Zhao Baosheng Du Haishui Zhu Yindi Xu Tunhai (Experimental Center of Scientific Research, Beijing University of Chinese Medicine, Beijing, 100029, China) ： ： Abstract: Objective To investigate the influence of Renshenbaihu Tang (RSBH) on diabetic peripheral neuropathy. Methods I.v. alloxan to estabmlish the rats diabetes model, then administrated RSBH for weeks, measured pain threshold of mechanical stimulation, sciatic nerve conduction velocity, and pathomorphology of sciatic nerve, analysed the influence of RSBH on rats diabetic ： peripheral neuropathy. Results RSBH obviously increased the rats pain threshold (P0.05 or P0.01), elevated the sciatic nerve conduction velocity, and markedly improved the denaturation of nerve fibre medulary sheath (P0.05 or P0.01), showed certain effect on anti- diabetic peripheral neuropathy. Keyword: Renshenbaihu Tang; diabetes