何首乌提取物二苯乙烯苷对东莨菪碱致学习记忆障碍模型小鼠的影响_叶翠飞.pdfVIP

# 叶翠飞 , 魏海峰, 张 丽, 张 兰, 李 林( 首都医科大学宣武医院药理研究室, 北京市 100053) R965 A 1001- 0408( 2004) 11- 0658- 03 目的:观察何首乌提取物二苯乙烯苷( TS ) 对东莨菪碱致学习记忆障碍模型小鼠的 响方法: 将小鼠随机分为空白对照 组模型组T S 组( 低高剂量组) 和阳性对照组(吡拉西坦), 分别灌胃给药, 之后造模并进行Morris 水迷宫测试和避暗测试结 果: 与模型组小鼠比较, 在Morris 水迷宫测试中, 空白对照组阳性对照组及TS 高剂量组小鼠搜索时间及搜索距离均明显缩短 ( P 005); 在避暗测试中, TS 组小鼠受电击次数明显减少(P 0 05) , 潜伏期延长结论:何首乌提取物TS 对东莨菪碱所致 小鼠学习记忆障碍具有一定的改善作用 二苯乙烯苷; 东莨菪碱;学习记忆障碍;小鼠模型 Effect of 2, 3, 5, 4 tetrah drox stilbene 2 O D lucoside on the Learnin and Memor Abilit of y y g g y y Mouse Dementia Models Induced b Sco olamine y p YE Cuifei, WEI Haifeng, ZHAN Li, ZHAN Lan, LI Lin( Pharmacology Laboratory of Xuanwu Hospital, Ca ital Universit of Medical Sciences,Bei in 100053) p y j g ABS RAC OBJECT IVE: To investi ate the effect of 2 , 3, 5, 4 tetrah drox stilbene 2 O D lucoside(TS ) on g y y g the learning and memory ability of mouse dementia models induced by scopolamineMETHODS: Mice were randomly divided into blank group, model group, T S groups(low dose, high dose) and positive control(Piracitam) groupAll the mouse were intra astricall administrated b dru sAfter makin model,all micewere sub ected to Morris water maze and assive avoidance g y y g g j p testsRESU LT S: Compared with model group, swimming time were significantly reduced in the blank group, positive control group and high dose of TS group during Morris water maze test ( P 005) TS could prolong latency of themouse dementia models and reduce error times durin ste throu h testCONCLUSION:T S can effectivel im rovethe learnin and memor g p g