泽泻提取物对正常及四氧嘧啶小鼠糖尿病模型的影响.pdfVIP

8 3 Vol. 8, No. 3 2002 6 Chinese Journal of Experimental Traditional Medical Formulae Jun. , 2002 杨新波, 黄正明, 曹文斌, 陈鸿艳, 田文辉, 王建华 ( 北京军医学院药理教研室, 北京 100071) : : ( RAE) : 90mgkg- 1 , ( Glu) (Trig) ( Chol) ( Amy) ( Ins) : RAE 7 Glu Trig RAE , RAE Ins Amy : ; ; ; : R28 : B : 100 9903(2002) Effect of Extract from Rhizoma Alismatis on Normal and Alloxan Model in Mice YANGXinbo, HUANG Zhengming , CAO Wenbin, CHENHongyan, TIAN Wenhui, WANGJianhua (Departnent fo harmacology, Beij ing Medical College fo LA , Beij ing , 100071, China) Abstract:Mice were injected with alloxan, 90mgkg, introcaudal veins, to induce diabetes. Blood glucose(Glu) , trig lyceride(Trig) , cholesterol( Chol) and pancreatic amylase( Amy) were determined by using Automatic Biochemistry Analy sor, and serum insulin( Ins) was determined by radioimmunoassay, the pathological examinations of pancreas and islets wee observed under light microscope. Results showed: RAE, 30gkg ig, reduced the bolldglucose in normal mice after a single administration.RAE( 1 , 30gkg ig) also decreased Glu and Trig after administration for 7 days in alloxaninduced hy perglycemic mice. Pathological examination manifested approximate normal pathology distinction in RAEtreated group. RAE also increased the release of INS, and was able to arise the lowered Amy in diabetic mice. Key words: extract from RhizomaAlismatis( RAE) ; diabetic animals; blood glucose( Glu) ; insulin( Ins) ( rhizoma alismatic, RA) , 10min) 9 % 1000ml, 1d, , ! - 1 ( 2000rmin , 10min) , , 1gml- 1 , 1ml 01 g [1] , ,