莪术油干预治疗DMBA诱导大鼠乳腺癌癌前病变的组织病理学研究_宋爱莉.pdfVIP

第 27 卷 第 12期 Vol. 27 N o. 12 2 0 09年 12月 CH INESE ARCH IVES OF TRAD IT OI NAL CH INESE M ED CI INE Dec. 2 0 0 9 DMBA 宋爱莉, 殷玉琨,李静蔚, 刘晓菲,胡 倩 (, 250011) : 目的:通过观察莪术油对乳腺 前病变造模大鼠乳腺组织病理形态的影响,探讨莪术油对乳腺 前病变的治疗作用方法:将 256只 SD大鼠随机分为空白对照组疾病模型组三苯氧胺组康莱特组及莪术油大 中小剂量组采用 DMBA 诱导乳腺 前病变造模, 第 2天开始进行干预治疗,分别于第 8周末第 10周末第 12 周末第 14周末进行组织病理学观察分析结果:疾病模型组与空白对照组比较,大鼠死亡率 前病变发生率 乳腺 发生率增高( P 0. 05)莪术油中小剂量组大鼠死亡率 前病变发生率乳腺 发生率降低,与病模 组及康莱特组比较差异显著( P 0. 05), 与三苯氧胺组比较无显著差异( P 0. 05)结论: 莪术油可降低乳腺 前病变造模大鼠的 变发生率及死亡率, 可在 前病变阶段预防逆转阻断乳腺 的发生发展 :乳腺 前病变;病理; 动物模型; 莪术油; 实验研究 : R737. 9 : A : 1673- 7717( 2009) 12- 2496- 04 Study of Cu rzerene Cur ing the An im alM odel O f B reast Precancer R ats induced by DM BA S NG A i-li, YIN Yu-kun, LI Jing-we,i LIU X iao-fe,i HU Q ian (HospitalA ffilicated to ShandongUniversity of TraditionalChineseM edicine, Jinan 250011, Shangdong, China) Abstrac:t O bj ect iv e: To research the effect of treating breast precancerw ith Curzerene by observed in Pathological Changes. M ethods: 256 SD rats were randomly divided into seven groups: the blank control group, the breast precancer model group, the comparative group of kanglaite, the comparative group of tamoxifen, large middle and small remedial groups ofCurzerene, Anmi almodel of rat breast precancerwas inducedw ith DMBA. Interpose treatmentwas performed the second day, effect and analysis of pathology the 8th 10th 12th and 14thweek. R esults: Comparedw ith the blank con- trol group, the rate ofdeath of the breast precancermodelgroup increased( P 0. 05) , the probability of cancer, pre- NE,