血清CA125、CEA、NSE和CYFRA21.docVIP

血清CA125、CEA、NSE及CYFRA211在肺癌中的诊断价值 　　作者：王波，刘颖，张竞 作者单位：解放军总医院 胸外科，北京 100853;解放军总医院第一附属医院 胸心外科，北京 100048 　　【摘要】 目的 探讨血清CA125、CEA、NSE及CYFRA211联合检测对肺癌的诊断意义。方法 216例肺部肿瘤患者(包括肺癌179例，肺部良性病变37例)，术前均常规放射免疫分析法检测血清中CA125、CEA、NSE及CYFRA211含量，依照术后病理诊断将患者分为肺癌组和肺部良性病变组，另选取30例健康志愿者，常规行血清CA125、CEA、NSE及CYFRA211检测，分析三组中各肿瘤标志物在血清中的含量以及单项检测、联合检测的敏感性和特异性，并行统计学分析。结果 肺癌组血清CA125、CEA、NSE及CYFRA211含量与肺部良性病变组和健康对照组比较差异均有统计学意义(P0.05)，四种肿瘤标志物联合检测的诊断价值明显提高。结论 血清肿瘤标志物联合检测有利于肺癌的临床诊断。 　　【关键词】 肿瘤标志物;肺肿瘤;联合检测 　　Diagnostic Value of Combined Testing of CA125, CEA, NSE and CYFRA211 in Iung Cancer 　　Wang Bo, Liu Ying, Zhangjing 　　(Department of Thoracic , PLA,General Hospital, Beijing 100853, China;Department of Thoracic,First Affiliated Hospital of PLA General Hospital,Beijing 100048, China) 　　Abstract： Objective To study the diagnostic value of combined testing of CA125, CEA, NSE and CYFRA211 in lung cancer. Methods We selected 216 cases of lung tumor patients,Their serum level of CA125, CEA, NSE and CYFRA211 were tested by normal radio immunoassay before operation. Then, according to pathologic diagnosis, they were divided into lung cancer group and lung benign lesion group. In addition, we selected 30 volunteers as control group. Then, the three groups serum level of CA125, CEA, NSE and CYFRA211 were tested. We analyzed the content in serum, their sensitivity and specificity of the single and combine test in tumor markers, and carry out statistical analysis.Results Serum level of CA125, CEA, NSE and CYFRA211 in lung cancer patients were significantly higher than those in normal groups (P0.05), and it was more effective in the diagnosis of lung cancer through the way of combining measurement of CA125, CEA, NSE and CYFRA211. Conclusion The combined tumor markers testing of CA125, CEA, NSE and CYFRA211 is a valuable method in diagnosis of lung cancer. 　　Key words： Tumor markers; Lung heoplasms; combined testing 　　目前，我国肺癌发病率已上升为恶性肿瘤发病率的第一位。早期诊断成为肺癌治愈的关键。常规胸部X线检查对早期