阿昔洛韦缓释片在不同介质中的释放研究.pdfVIP

闃挎様娲涢煢缂撻噴鐗囧湪涓嶅悓浠嬭川涓殑閲婃斁鐮旂┒ 1锛?锛 1 1 1锛? 鍛 鍗 锛岃阿 娴 锛屼弗鐩稿钩 锛屼竵閫告 锛?.鍗椾含宸ヤ笟澶у姹熻嫃鐪佽嵂鐗╃爺绌舵墍鏈夐檺鍏徃锛屽崡浜競 210009锛?.鍗椾含 宸ヤ笟澶у鑽闄紝鍗椾含甯 210009锛 涓浘鍒嗙被鍙 R978.7 鏂囩尞鏍囪瘑鐮 A 鏂囩珷缂栧彿 1001-0408锛?011锛?1-2002-03 鎽 瑕 鐩殑锛氱爺绌堕樋鏄旀礇闊︾紦閲婄墖鍦ㄤ笉鍚屼粙璐ㄤ腑鐨勪綋澶栭噴鑽壒鎬с€傛柟娉曪細浠ヨ浆绡硶杩涜婧跺嚭搴︾爺绌讹紱閲囩敤绱鍒嗗厜鍏夊害娉曞湪 254nm 娉㈤暱涓嬫祴瀹氶樋鏄旀礇闊︾紦閲婄墖鍦?绉嶉噴鏀句粙璐ㄥ嵆0.1mol 路L锛?鐩愰吀娑层€乸H6.8纾烽吀鐩愮紦鍐叉恫銆佽捀棣忔按鍜岀敱0.1mol 路L锛?鐩愰吀娑 锛堝墠2h 锛変笌pH6.8纾烽吀鐩愮紦鍐叉恫锛?h 鍚庯級缁勬垚鐨勬浛鎹粙璐ㄤ腑鐨?2h 鍐呯殑閲婃斁搴︼紝骞惰繘琛岄噴鏀捐涓烘ā鍨嬬殑鎷熷悎銆傜粨鏋滐細闃挎様娲涢煢缂撻噴 鐗囧湪鐩愰吀娑蹭腑鐨勯噴鏀鹃€熷害鏈€蹇紝浣?2h 鏃?绉嶄粙璐ㄤ腑闃挎様娲涢煢鐨嗛噴鏀惧畬鍏紱闃挎様娲涢煢鍦?绉嶄粙璐ㄤ腑浣撳閲婅嵂鎷熷悎妯″瀷鏇存帴杩慔igu- chi 鏂圭▼鍜孭eppas 鏂圭▼銆傜粨璁猴細闃挎様娲涢煢缂撻噴鐗囧湪涓嶅悓浠嬭川涓潎鍏锋湁缂撻噴鎬э紝閲婃斁鏈哄埗涓昏涓烘墿鏁ｉ噴鑽€ 鍏抽敭璇 闃挎様娲涢煢锛涚紦閲婄墖锛涗綋澶栭噴鑽紱浠嬭川 Drug Release of Aciclovir Sustained-release Tablets in Different Media ZHOU Wei 锛孹IE Hao 锛孻AN Xiang-ping 锛孌ING Yi-mei 锛圝iangsu Institute of Materia Medica Co. 锛孡td. 锛孨anjing University of Technology 锛孨anjing 210009锛孋hina 锛 ZHOU Wei 锛孌ING Yi-mei 锛圫chool of Pharmaceutical Sciences 锛孨anjing University of Technology 锛孨anjing 210009锛孋hina 锛 ABSTRACT OBJECTIVE 锛歍o study the release characteristics of Aciclovir sustained-release tablets in vitro. METHODS 锛欴rug release rate study was conducted using basket method. The drug release rates of Aciclovir sustained-release tablets in 4kinds of me- dia at wavelength of 254nm for 12h were determined by UV spectrophotometry 锛宨.e. 0.1mol 路L锛? hydrochloric acid 锛宲H6.8phos- phate buffer solution 锛宒istilled water and pH 6.8 phosphate buffer solution instead of 0.1mol 路L 锛? hydrochloric acid 2 h later. RE- SULTS 锛歍he drug release of Aciclovir sustained-release tablets was the fastest in hydrochloric acid. 12 h later 锛孉ciclovir sus- tained-release tablets was released completely in 4 kinds of media. In vitro drug release of Aciclovir sustained-release tablets was consistent with Higuchi equation and Peppas equation in 4 kinds of media. CONCLUSION 锛