反流致大鼠Barrett#39;s食管及其腺癌过程中诱导型一氧化氮合酶的表达及意义.pdfVIP

150 第四军医大学学报（J Fourth MiI Med Univ ）2005 ；26（2 ） http ：/ / journaI. fmmu. edu. cn ·研究原著 · 文章编号：1000-2790 （2005 ）02-0 150-04 反流致大鼠Barrett s 食管及其腺癌过程中诱导型一氧化氮合酶的表达及 意义 1 1 2 1 1 1 张 涛 ，朱以芳 ，张 峰 ，王云杰 ，程庆书 ，李小飞 1 2 （第四军医大学：唐都医院胸外科，陕西 西安7 10038 ，基础部药理学教研室，陕西 西安7 10033 ） ———————————————————————————————————————————————— Expression and significance of inducible observed. The incidence of BE and EAC increased with time ：37. 5% and 0% at week 8 ，60% and 10% at week 12 ， nitric oxide synthase in formation of 90% and 30% at week 16 ，86 . 6% and 53. 3% at week 20 . Barrett s esophagus and its progression lmmunohistochemical staining of iNOS was negative in to esophageal adenocarcinoma in a rat the control group. ln the model group positive expression of iNOS in the distal one-third of the esophagus was observed model in 0% ，0% ，50% ，80% ，100% and 100% of the rats at ZHANC Tao1 ，ZH U Yi-Fang 1 ，ZHANC Feng2 ，WANC Yun-j ie1 ， week 1，4 ，8 ，12 ，16 and 20 respectively and in 100% of the CHENC Oing-shu1 ，LI Xiao-Fei1 rats with BE and EAC. Positive iNOS staining was observed 1 Department of Thoracic Surgery ，Tangdu ~ospitaI ，Xifan 7 10038 ， in the stromal macrophages directly beneath the epith