止痢颗粒抗菌作用及急性毒性实验的研究.pdfVIP

止痢颗粒抗菌作用及急性毒性实验的研究 吴丽燕，郭喜红，于鲁海(新疆维吾尔自治区人民医院药剂科，乌鲁木齐市830001) 中图分类号R965 文献标识码B 文章编号1672—212412007)05—0383—02 摘 要 目的：研究止痢颗粒对大肠杆茵和痢疾杆茵感染小鼠的抗茵作用及对小鼠的急性毒性实验。方法：将小鼠随机分为阴性 荆量时对痢疾杆茵感染小鼠有明显的保护作用。急性毒性实验表明小鼠口服最大给药量相当于临床用量(t5s／袋)104倍，口服安 全。结论：止痢颗粒具有明显抗茵作用，口服安全无毒。 关键词 止痢颗粒；抗茵作用；小鼠；急性毒性实验 ’ AntibacterialActionandAcute TestsofZhifiGranule Toxicity WU of of Liyan，GUOXihong，YULuhai(DeptPharmacy，People’SHospitalXinjiangUygur 830001，China) Regions，Urumqi ABSTRACT of with bacilli OBJECTIVE：ToantibacterialeffectsZhili onmiceinfectedE．colior study granule dysentery anditsacute on wererandomizedtonormalcontrol control andzhifi mice．METHODS：Mice toxicity group，positivegroup were with granule injectedintmperitoneallyquantitative groups(2．59。kg～，5．Og。kg～and10．09’kg“)．仙mice bacteriumsolutions30minutesto administered with medicinesonce for7 priorbeing intragastricallycorresponding daily numberof WaS a of zhili consecutive deadmiceineach recorded．RESULTS：Atdose days．The group 5．89。kg一1 granule had anti—infectiveeffectonmiceinfectedE．coliandatadoseof had anti—infectiveeffecton good by 10．09。kg～itgood showedmaximaltoleranceof micetozhili miceinfected bacterium．Acutetext that bydysentery toxicity