粉针分装过程中影响粉针剂质量的因素.pdfVIP

MedicineJournalV01．17NO．32004 黑龙江医药 HeiLongJiang 粉针分装过程中影响粉针剂质量的因素 杜滨董艳峰 哈药集团制药总厂(150086) 摘要 目的：为了减少抗生素粉针剂在有效期内发生结块、变黄问题。方法：通过对粉针分装工 艺进行研究及对比实验，总结粉针分装过程中使粉针结块变黄的几个因素：西林瓶干燥灭茵情况； 胶塞的吸湿性及透气性；铝盖及封蜡严密度。结论：为减少粉针剂结块、变黄，西林瓶在红外线隧道 中的干燥灭菌段应停留5分钟以上，胶塞与西林瓶密封严密，铝盖不松动，沾蜡均匀、严密。 关键词 粉针剂；西林瓶；胶塞；铝盖 The ofthe inthe studyingquantity’sfactory lOading ofthe medicinefor process powder injection a1． Dubin，et H以，‘6f挖P^口，期口cP“fic口Z G已咒Pr口Z G，．o。驴∞．L77D P^口，‘7竹．Fkc￡o，≯ Abstract decrease and oftheantibiotic Objective：Toagglomerationbecomingyellow pow— thattake termof and dermedicinefor inthe result：Wehave injection place validity．Method sumedafewfactorthat the medicinefor to andbecome powder injection up making agglomerate the of andthecontrast ofbot— yellowthroughstudyingtechnologyloading experi“lent．thedrying ofthe cork．the thealuminum wax tle．thecloseness of coverand gum density Todecrease and ofthe medicinefor bottle yellow power injection，the agglomerationbecoming shouldoverfiveminutesintheinfrared corkand bottleis alu— bunnel，the the close，the