空腹血糖受损冠心病患者冠脉病变特点与血高敏C反应蛋白的关系.docVIP

空腹血糖受损冠心病患者冠脉病变特点与血高敏C反应蛋白的关系 　 作者：李嘉，陈鹏，季亢挺 杨鹏麟 作者单位：温州医学院附属第二医院心血管内科，浙江温州 325027 　　【摘要】 目的 探讨空腹血糖受损(IFG)冠心病患者冠状动脉病变特点，与血高敏C反应蛋白(hs_CRP)水平的关系及意义。方法 对经冠脉造影确诊的冠心病患者行口服葡萄糖耐量试验(OGTT)，据结果用1999年WHO标准选取冠心病合并IFG组69例，另设糖代谢正常冠心病组64例(对照组)。测定两组体重、血压、血脂、血肌酐、血hs_CRP，记录其年龄、冠心病危险因素(性别、高血压、高胆固醇血症、吸烟)和冠状动脉造影结果并计算冠脉病变积分。结果 血hs_CRP水平、冠脉病变积分在IFG组较对照组明显升高(P0.01);相关分析显示，在冠心病合并IFG患者中，空腹血糖水平、血hs_CRP水平与冠脉病变Gensini评分呈正相关(r分别=0.2685，0.5232 均P0.05)。结论 冠心病合并IFG患者冠脉病变严重，多支冠脉病变发生率高，病变呈弥漫性狭窄。冠心病合并IFG患者存在炎症反应，血hs_CRP水平与冠脉狭窄程度相关。 　　【关键词】 冠状动脉疾病;空腹血糖受损;口服葡萄糖耐量试验;超敏C反应蛋白;冠脉狭窄程度积分;冠状动脉造影 　　The Relationship between hs_CRP Level and Coronary Artery Lesion in Coronary Heart Disease Patients with Impaired Fasting Blood Glucose. LI Jia, CHEN Peng, JI Kang_Ting， et al. Department of Cardiology, the Second Affiliated Hospital of Wenzhou Medical College, Zhejiang, 325027, China. 　　[Abstract] Objective To explore the relationship between the level of high_sensitive C_reactive protein (hs_CRP) and the severity of coronary artery lesions in coronary heart disease patients(CHD) with impaired fasting glucose(IFG). Methods According to the oral glucose tolerance test(OGTT) results of standard of WHO in 1999， 133 CHD confirmed by coronary angiography were divided into two groups：69 cases with impaired fasting glucose (IFG group) and 64 patients with normal OGTT (control group). For all the patients, age， body weight, blood pressure, blood_lipid, serum creatinine, hs_CRP， CHD risk factors (sex, hypertension, hyper_cholesteremia, smoking) and coronary angiography results were recorded and the coronary narrow degree integral was calculated. Results Plasma hs_CRP level and coronary narrow degree integrals were higher in IFG group than those in control group(P0.01). Correlation analysis showed that the fasting blood glucose and plasma hs_CRP level in CDH with IFG were positively correlated with the coronary narrow degree integrals (r=0.2685 and 0.5232. respectively P0.05). Conclusions The coronary mul