癫痫患者颞叶脑皮质中发现Notch1信号通路地过度表达.docVIP

癫痫患者颞叶脑皮质中发现Notch1信号通路的过度表达 Notch1信号通路过度激活参与神经胶质瘤中星形胶质细胞的增殖过程，但是否也参与癫痫的发病尚不清楚。中国华中科技大学刘希金所在团队一项关于“Increased expression of Notch1 in temporal lobe epilepsy: animal models and clinical evidence”的研究，发现Notch1信号通路在颞叶癫痫大鼠脑组织中存在过度表达，调节Notch1信号通路表达水平后，可以相对有效的减少癫痫的发作频率，减少大脑放电，使得癫痫有一定程度的缓解。临床观察也证实，顽固性颞叶癫痫患者颞叶皮质中Notch1和Hes1表达增加。由此推测Notch1可能在颞叶癫痫的发病中发挥重要作用，阻滞Notch1信号通路可能是治疗颞叶癫痫的一种新方法。相关研究结果发表在《中国神经再生研究（英文版）》杂志2014年3月第5期。 免疫染色显示顽固性颞叶癫痫患者颞叶皮质中Hes1表达增加 Article: Increased expression of Notch1 in temporal lobe epilepsy: animal models and clinical evidence, by Xijin Liu, Zhiyong Yang, Yaping Yin, Xuejun Deng (Department of Neurology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei Province, China) Liu XJ, Yang ZY, Yin YP, Deng XJ. Increased expression of Notch1 in temporal lobe epilepsy: animal models and clinical evidence. Neural Regen Res. 2014;9(5):526-533. 欲获更多资讯：Neural Regen Res Overexpression of Notch1 in temporal lobe epilepsy Notch1 signaling can induce astrogliosis in glioma. However, it remains unknown whether Notch1 signaling is involved in the pathogenesis of epilepsy. A recent study by Xijin Liu and co-workers from Huazhong University of Science and Technology in China observed overexpression of Notch1 in the brain tissue of temporal lobe epilepsy rats. After Notch1 regulation, it was relatively effective in reducing seizure frequency and reducing brain discharges, thereby resulting in the ease of seizures to a certain extent. Increased presence of Notch 1 and hairy and enhancer of split-1 was also observed in intractable temporal lobe epilepsy patients. Therefore, Notch signaling may play a role in the pathogenesis of epilepsy in temporal lobe epilepsy and its suppression may provide a new treatment to promote remission in epilepsy. These findings were published in the Neural Regeneration Research (Vol. 9, No. 5, 2014). Increased presence of hairy and enhancer of split-1 in the temporal neocortex of in