免疫，慢性病.pdfVIP

Nutrition xxx (2010) 1–6 Contents lists available at ScienceDirect Nutrition journal homepage: Review Current perspectives on vitamin D, immune system, and chronic diseases Maria C. Borges M.D., Lígia A. Martini Ph.D., Marcelo M. Rogero Ph.D. * Department of Nutrition, School of Public Health–University of São Paulo, São Paulo, Brazil a r t i c l e i n f o a b s t r a c t Article history: Accumulating data support that vitamin D possesses several biological and molecular actions apart Received 11 May 2010 from its role in calcium homeostasis. Immune cells express vitamin D receptor and are capable of Accepted 30 July 2010 metabolizing vitamin D. Within this context, experimental studies show that vitamin D modulates immune and inflammatory responses. Epidemiologic evidence linking poor vitamin D status to Keywords: autoimmune diseases, type 2 diabetes, and cardiovascular disease suggests that insufficient Vitamin D vitamin D may be involved in the etiology of such disorders. Given the impact of immune and Immune diseases inflammatory abnormalities in the development of chronic diseases, including autoimmune Inflammation Diabetes disorders, it is possible that vitamin D might reduce chronic disease risk by modulating the Cardiovascular disease