紫杉醇聚氰基丙烯酸正丁酯纳米粒制备研究.pdfVIP

南方医科大学学报USouthMed ·763· 2010；30(4) Urdv) 紫杉醇聚氰基丙烯酸正丁酯纳米粒制备研究 陈如大，任非，李国锋，刘思佳(南方医科大学南方医院药学部，广东广州510515) 摘要：目的评价紫杉醇聚氰基丙烯酸正丁酯纳米粒(PTX-PBCA-NPs)的不同制备工艺对紫杉醇的包封率和载药量的 影响。优选PTX．PBCA．NPs的制备工艺。方法以包封率和载药量为主要评价指标，分别采用界面缩聚法和乳化聚合 包封率符合药典要求。经比较研究，界面缩聚法可能是提高PTX．PBCA-NPs载药量较好的一种制备方法(P0．05)。 关键词：紫杉醇；聚氟基丙烯酸正丁酯；纳米粒；界面缩聚：乳化聚合 中图分类号：R944 文献标识码：A 文章编号：1673-4254(2010)04．0763．04 of Preparationpaclitaxel—loadedpolybutylcyanoacrylatenanoparticles CHEN Ru-da，KENFei，LIGuo-feng，LIUSi-jia Department Medical 510515，China ofPharmacy，NanfangHospital，SouthernUniversity，Guangzhou Toevaluatetheeffectofdifferent methodsonthe Abstract：Objective preparation encapsulationefficiency(EE)anddrug the of loading(DL)ofpaclitaxel—loadedpolybutylcyanoacrylatenanoparticles(PTX-PBCA-NPs)andoptimizepreparation PTX．PBCA-NPs．MethodsWithDLandEEasthe indexes．theofPTX．PBCA-NPsthe major qualities producedby were was interfacialpolymerizationandemulsion method obtained polymerizationcompared．Theoptimizedprescription by ResultsThe ofEEofPTX．PBCA．NPswiththetwomethodswereboth94．39％．99．23％．The orthogonaldesign． ranges DLwithinterfacial emulsion highest polymerizationWas(1．07±0．03)％，ascomparedto(0．86iq)．01)％withpolymerization． in The conditionsresutedthemeansizeofP1’x—PBCA．NPsof235．6 of0．80％．andEEof optimizedpreparation nln,DL 95．71％．ConclusionsTheEEofPTX．PBCA．NPstheabovetwomethodsisconsistentwiththe of preparedby requirement