实例血管内皮生长因子诊断和监测卵巢恶性肿瘤的临床研究.pdf

2001 6 17 6 353 : 1005- 2216( 2001) 06- 0353- 03 曹树军 张吉才 刘永珍 陈双郧 罗 仪 卵巢肿瘤 血管内皮生长因子 病情监测 血管生成 讨血管内皮生长因子( VEGF) 对卵巢恶性肿瘤的诊断和病情监测作用 收集卵巢肿 瘤65 例为研究对象, 采用酶联免疫法动态检测血清VEGF 水平, 内胚窦瘤病例同时放免测定血清甲胎蛋白 ( AFP) 水平 卵巢恶性肿瘤术前血清VEGF 水平明显高于卵巢良性肿瘤和健康妇女, 晚期病例明显高 于早期病例, 均有极显著差异 血清VEGF 与AFP 水平均随卵巢恶性肿瘤病情控制而变化, 且两者呈高度正 相关动态监测血清VEGF 水平诊断卵巢恶性肿瘤及其分期和预后的准确性均在 80% 以上 血清 VEGF 水平与卵巢恶性肿瘤的生长转移和预后有密切关系, 具有肿瘤标志物特性, 可作为卵巢恶性肿瘤的诊断 和病情监测指标 : R7 1 : A Study on clinical application of vascular endothelial growth factor in diagnosis and monitoring of ovarian malignant tumour Cao Shuj un, Zhang Jicai, Liu Yongzhen, et al. Taihe Hospital of Yunyang Medical College, Shiyan, 442000, China Key words Ovarian ne plasm Vascular end thelial gr w th fact r Illness m nit ring Angi genesis Abstract Obj ective T study the r les f vascular end thelial gr wth fact r( VEGF) n the diagn sis and m nit r ing f varian malignant tum ur . Methods 65 varian ne plasms w ere c llected. Serum VEGF levels w ere c nt inu usly determined by enzym immun assay bef re and after perati n, serum A FP in patients w ith end dermal sinus malignant tum ur w ere m nit red by radi immun assay . Results Serum VEGF levels bef re perati n in patients wit h varian malignant tum ur were significantly higher than th se with benigh nes and the healthy c ntr ls. Serum VEGF levels in patients w ith advanced stage varian malignant tum ur were apparently higher than th se at early stage. Serum VEGF levels had a p sitive c rrelati n with the AFP levels, and they pr gressively dr pped under the c ntr l f illness. Serum VEGF levels c uld be used t diagn se varian malignant tum ur, determine the