转录因子相关数据库.pdfVIP

HEREDITAS (Beijing) 2010 10 , 32(10): 1009―1017 ISSN 0253-9772 综述 DOI: 10.3724/SP.J.1005.2010.01009 转录因子相关数据库 陈鸿飞, 王进科 , , 210096 转录水平的调控是基因调控的重要环节, 其中转录因子(Transcription Factor, TF)和转录因子结合位点 (Transcription Factor Binding Site, TFBS)是转录调控的重要组成部分。为了解析基因转录调控过程中TF 与其 TFBS 相互作用的分子机理, 鉴定TFBS 及构建基因转录调控网络, 需要对已发现的TF 及其TFBS 信息进行系 统的收集、整理和分析。目前, 国际上已经出现不少关于TF 及其TFBS 的专业数据库, 这些数据库对基因转录 调控及 TF 相关的分子生物学、系统生物学及生物信息学的研究非常重要, 对这些领域的研究起到了显著的推 进作用。文章对7 个目前比较著名的TF 及其TFBS 相关数据库, 包括TRANSFAC 、JASPAR 、TFDB 、TRRD 、 TRED 、PAZAR 、MAPPER 的特点、数据种类和数量及使用方法进行了详细综述, 并简要介绍了其他相关数据库。 转录因子; DNA 结合位点; 数据库; 生物信息学 The databases of transcription factors CHEN Hong-Fei, WANG Jin-Ke The State Key Laboratory of Bioelectronics, The Experimental Center of Biotechnology and Biomaterials, School of Biological Sciences and Medical Engineering, Southeast University, Nanjing 210096, China Abstract: The control of gene transcription is a critical level of gene expression regulation. The interactions between transcription factors (TF) and their DNA binding sites (TFBS) play a key role at this level. In order to decipher the molecu- lar mechanism of the interactions of TFs with TFBSs and construct transcription regulatory network, it is necessary to sys- tematically collect, save, and analyze the information of discovered TFs and their TFBSs. In recent years, multiple TF and TFBS-related databases have been established. These databeses significantly promoted the TF-related studies in the fields of molecular biology, bioinformatics, and system biology. This paper summarized the contents, characteristics, access, and advances of main TFs and