家族性复发性葡萄胎的临床特征及遗传学分析.pdfVIP

2006 3 41 3 C in J Obstet Gynecol, Marc 2006, V ol41, N o3 177 赵峻 向阳 黄尚志 万希润 董敏 胡韶毅 何莲芝 杨秀玉 ! ( FRM ) 2 FRM , 2 FRM 6 DNA , 2 FRM ( B iCHM ); 6, 1, 5 2 FRM , , ( ) , , FRM B iCHM, , ! ; ; () * C lin ical character ist ics and gene tic analy ses of fam ilial recurren t m oles ZH A O Jun , X IAN G Yang, H UAN G Shangzh ,i WAN X irun, DON G M in, H U Shaoy ,i HE L ianzh i, YANG X iuyu * D ep ar men of O bs e rics and Gynecology, P ek ing Union M edical Co lleg e H osp i al, P ek ing Union M edical Colleg e, Ch inese A cademy of M ed ical Sc ience, B eji ing 100730, Ch ina Corresp onding au hor: X IANG Yang, 100 730 D ep ar m en of O bs e rics and Gy necology, P eking Union M ed ical C olleg e H o sp i al, P ek ing Union M ed ical Co llehe, Ch inese A cademy of M ed ical S cience A bstract! O bj ective To probe t e clin ical c aracteristics and genetic origin of fam ilial recurrent m ole ( FRM ) M e thod s Tw o cases of FRM w ere reported retrospectivelyM icrosatellite polym orp ism w as used to determ ine t e genetic origin of t e tw o FRM and ot er six sporadic m oles from ot er independent fam iliesR esults T e tw o FRM patients cam e from two independent fam iliesBot of t em ad m ore t an two tmi es of ydatidiform moles and t e sam e condition ad appened to t eir sistersT e last mole from eac of t ese two patientswas identified as b iparental com plete ydatidiform mole ( B iCHM ) Am ong t e s ix sporadicm oles, one was partial ydatidiform mole ( PHM ), w ic w as iden tified as trip loidw it one ap loid m aternal set of c rom osom es and two ap loid paternal sets of c rom osom es T e ot er five sporad ic moles w ere all androgenetic com plete ydatid iform mole (AnCHM ), w ic lacked m aternal geneticm a