食管癌新辅助化疗后手术和单纯手术生存比较的Meta分析.pdfVIP

2010 1 9 Journal of Clinical Medicine in Practice 21 Meta 1 1 1 2 1 刘凌翔, 高 雯 , 黄普文, 柏建岭 , 束永前 ( 1. , , 210029; 2. , , 210029) : ( CS ) ( S ) PubM ed ( RCT) , stata v. 10. 0 , , 10 RCT ( 2 080 ) S , CS , HR 0. 95( 95% CI 0. 86- 1. 0 ) , , HR 0. 58( 95% CI 0. 7- 0. 72) ; CS S , OR 1. 05( 95% CI 0. 87- 1. 27) , , : ; ; Meta : R 7351 : A : 2010) Survival benefits from neoadjuvant chemotherapy in esophageal cancer: ameta- analysis 1 1 1 2 1 LIU Lingxiang , GA Wen , HUANGPuwen , BAI Jianling , SHU Yongqian ( 1. Dep ar tment of Oncology F ir st Af f iliated H osp ital of N anj ing M ed ical Univ ersity , Jiangsu , N anj ing , 210029 2. School of P ublic H ealth, N anj ing Medical Un iv ers ity , J iang su, N anj ing , 210029) ABSTRACT: bjective To evaluate the efficacy and safety of neoadjuvant chemotherapy ( CS group) or surgery alone ( S group) in the treatment of esophageal cancer. Methods Entries in PubM ed, Wanfang, etc. database w ere searched for RCT ( Randomized clinical trials) on neoadju- vant chemotherapy or surgery alone for esophageal cancer to Jan. 2010 in English and Chinese w ith reference to selection criteria in the study . Stata v. 10. 0 softw are w as used for the analysis. Results 10 RCT s, 2080 patients w ith esophageal cancer, were enrolled. Compared w ith S group, CS group did not significantly prolong the survival in esophageal cancer, w ith a pooled HR 0. 95 ( 95% CI 0. 86- 1. 0 ) , how ever the effective n