《EFFECTS OF INHALED TiO2 NANOTUBES ON LUNG TISSUE AND SERUM BIOCHEMICAL INDEXES OF MICE》.pdfVIP
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Mar.2013 Transactionsof ofAeronauticsAstronauticsVol。30No.1
University
Nanjing
EFFECTSOFINHALEDNANOTUBESONLUNGTISSUE
Ti02
ANDSERUM INDEXESOFMICE
BIOCHEMICAL
Tao
Jie(陶杰),HePinting(何娉婷),ZhangYanyan(张焱焱)
TangYuxin(汤育欣),WangYueqin(王月勤)
ofMaterialScienceand ofAeronautics
(College University
Technology,Nanjing
and
Astronautics,Nanjing,2i0016,P.R.China)
Abstract:Toevaluatetheacute andtheeffectonserumbiochemicalindexesofinhaled nano—
lungtoxicity Ti02
andadult miceare toaerosolsof nanotubesinasealedchamber,theeoncen—
tubes,healthyKunming exposed Ti02
trationof is of to air
which250 whileanother miceare room servedascontr01.The
mg/m3 group exposed only
blood,alveolarfluidand ofthemicearecollectedandexaminedafter for7,14and28d,re—
lavaged lungs exposed
serum 7
showsthat withd aminotransferase(AI。T)
spectively.Theanalysis glucose(Glu)valuesexposure.alanine
and aminotransferase(AST)activitieswith28dinhalation,andtotalbileacid(TBA)valueswith7,28d
aspartate
aswellasthe 28
creatinekinase(CK)levelswithd are differentfromthoseofcontrols(P
exposuresignificantly
0.05).The exhibitthatmore nanotubesarefoundintheinterstitiumof aIve—
pat
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