Synthesis and Drug.pptVIP

Synthesis and Drug-Delivery Behavior ofChitosan-Functionalized Graphene OxideHybrid Nanosheets 报告人： 焦 萍 专 业：制药工程 contents The modification of Go Modification The modification of Go Chitosan (CS) is a biocompatible, biodegradable and non-toxic natural polymer and has applications in wound healing, tissue repair,anti-microbial resistance,cell adhesion and food delivery. FGOCs were found to significantly improve the solubility of the GO in aqueous acidic media. The modification of Go Infrared spectroscopy (FT-IR),thermogravimetric analysis (TGA), and X-ray photoelectron spectroscopy (XPS) confirmed the functionalization of graphene with chitosan and the exfoliation of FGOCs. The restoration of the sp2carbon network on the basal planes of the graphene sheets was confirmed by Raman spectroscopy and wide-angle X-ray diffraction (WAXD) Drug Loading Drug Loading Drug releasing Conclusion In summary, GO was successfully functionalized with chitosan. The excellent exfoliation and dispersion of the functionalized graphene sheets in the aqueous acetic acid solution presented here suggests that this method could be used to produce exfoliated, reduced graphene sheets. Conclusion Moreover,IBUand5-FU were loaded successfully on FGOCs sheets, despite lower numbers of p electrons. Controlled release behavior and long term biocompatibility of FGOCs graphene sheets suggest that these graphene sheets are promising novel materials for biomedical applications.This facile and low cost process could improve the commercial applications of graphene materials. * LOGO The modification of Go Drug loading Drug releasing (GO) (FGOCS) MODIFICATION The difference in the loading ability of the drugs is ascribed to the difference in their chemical structures and interactions with FGOCs. drug loading ratio: IBU : 0.097mg/mL 5-FU :0.053mg/mL The significantly different IBU release behavior from FGOCs g