《Lipopolysaccharide Challenge Induces Long Pentraxin 3 Expression in Mice Independently from Acute Lung Injury（英文版）》.pdfVIP

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《Lipopolysaccharide Challenge Induces Long Pentraxin 3 Expression in Mice Independently from Acute Lung Injury（英文版）》.pdf

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Chin Med Sci J Vol. 30, No. 1 March 2015 P. 7-17 CHINESE MEDICAL SCIENCES JOURNAL ORIGINAL ARTICLE Lipopolysaccharide Challenge Induces Long Pentraxin 3 Expression in Mice Independently from Acute Lung Injury△ 1† 1† 2 3 1 Gao Zeng , Jie Liu , Ning Wu , Cong-wei Jia , and Shu-bin Guo * 1Department of Emergency Medicine, 3Department of Pathology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences Peking Union Medical College, Beijing 100730, China 2Department of Thoracic Surgery, Huashan Hospital, Fudan University, Shanghai 200040, China Key words: long pentraxin 3; acute lung injury; biomarker; sepsis; lipopolysaccharide Objective To determine whether the onset of acute lung injury (ALI) induces the up-regulation of pentraxin 3 (PTX3) expression in mice and whether PTX3 concentration in the biofluid can help recognizing sepsis-induced ALI. Methods Wild-type C57BL/6 mice (12-14 weeks old) were randomly divided into 3 groups. Mice in the group 1 (n=12) and group 2 (n=12) were instilled with lipopolysaccharide via intratracheal or intraperitoneal routes, respectively. Mice in the group 3 (n=8) were taken as blan