《Liquid chromatography coupled with timeofflight and ion trap mass spectrometry for qualitative analysis of herbal medicines》.pdfVIP
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)urnalofPharmaceuticalAnalysis2011;1(4):235—245
因 JournCaonltwoenwfWtwPsWWheist.lasseavsrve.maeeirniaibclc【aeo.mdcelraieeutoclStcCatcOm.t/eciienapcjeDalAri/ecntaylsis
EVIEW PAPER
~liioquuiiddcchhrroommaattooggrraapphhyycoupplieeadwWIitth11ttiimmee-..OofI-nfliigghhtt
mdiontrapmassspectrometryf一orqua一l-itat-ive
malysisofherbalmedicines ·
a0.FeiChena,v,Hai.TangW u ,v,Guang.GuoTan ,
5hen.YuZhua,v.Yi.FengChaia,b,术
DepartmentofPharmaceuticalAnalysis,SchoolofPharmacy,SecondMilitaryMedicalUniversity,Shanghai200433,China
ShanghaiKeyLaboratoryfo,PharmaceuticalMetaboliteResearchShanghai200433,China
:eceived 1August2011;accepted7September2011
Lvailableonline21October2011
KEYW ORDS Abstract Withtheexpansionofherba1medicine(HM)market,theissueonhow toapplyup—to—
dateanalyticaltoolsonqualitativeanalysisofHM stoassuretheirquality,safetyandefficacyhas
Highperfomr ance
beenarousinggreatattention.Dueto itsinherentcharacteristicsofaccuratemassmeasurements
liquidchromatography
andmultiplestagesanalysis,theintegratedstrategyofliquidchromatography(LC)coupledwith
(HPLC);
Time.of-flightmass time—of-flightmassspectrometry(TOF.MS)andiontrapmassspectrometry(IT—MS)iSwell—suited
tObeperformedasqualitativeanalysistooIinthisfield.Thepurposeofthisreview iStoprovidean
spectrometry
(TOF—MS); overview on thepotentia1ofthisintegratedstrategy,includingthereview ofgeneralfeaturesof
Iontrapmass LC—IT—M SandLC—T0F—MS,theadvantagesoftheircombination,thecommon proceduresfor
spectrometry(IT—MS): structureelucidation.thepotentialofLC—hybrid.IT—TOF/MSandalsothesummaryanddiscussion
Herbalmedicine(HM) oftheapplicationsoftheintegratedstrategyofrHM qualitativeanalysis(2006-20
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