一种新型苯乙酮衍生物诱导人早幼粒白血病HL-60细胞凋亡机制研究.pdf

The mechanism of apoptosis induced by a novel acetophenone derivative in human leukemia HL-60 cells Han Xiao 目 录 摘 要I Abstract III 第一章 综 述 1 1 肿瘤与细胞凋亡的关系 1 1.1 抗凋亡因素的调控·························································································· 1 1.1.1 Bcl-2 与肿瘤细胞凋亡调控 ······································································ 1 1.1.2 凋亡抑制剂 IAPS 与肿瘤细胞凋亡调控 ·················································· 1 1.1.3 XIAP 与肿瘤细胞凋亡调控······································································ 2 1.1.4 Survivin 蛋白与肿瘤细胞凋亡调控·························································· 2 1.1.5 死亡受体阻断分子···················································································· 2 1.2 促凋亡因素的调控·························································································· 3 1.2.1 p53 基因野生型 ························································································ 3 1.2.2 C-m