扑热息痛及类似物的合成新工艺研究.pdfVIP

中文摘要 本论文包括以下四章： 第一章：对乙酰氨基酚的合成进展 本章综述了近年来由不同起始原料合成对乙酰氨基酚的方法，通过对不同起始原料及 其方法的比较，从环保上和经济上来考虑，认为以苯酚为原料的一锅合成方法将是对乙酰 氨基酚合成的较好方法。 第二章：一种合成乙酰胺基苯酚的新工艺 本章以锌粉作催化剂和抗氧剂，以对氨基苯酚和冰醋酸为原料，高纯度，高收率地合 成了APAP。产物经熔点测定和核磁共振氢谱表证。最后评述了该工艺的优点。 第三章：一锅法合成对乙酰胺基酚的新工艺 本章研究了在PPA作催化剂的情况下，以苯酚，冰乙酸，盐酸羟胺为原料一锅法合成对 乙酰氨基酚的新工艺。产物经熔点测定和核磁共振氢谱表证。最后评述了一锅法合成对乙 酰胺基苯酚的工艺优点。 第四章：一锅法合成扑热息痛类似物的新工艺 本章研究了在PPA作催化剂的情况下，以苯酚，丙酸或正丁酸，盐酸羟胺为原料一锅法 合成扑热息痛类似物的新工艺。产物经熔点测定和红外光谱表证。 关键词：合成；催化剂；对氨基苯酚；对乙酰胺基苯酚；扑热息痛类似物；一锅法； 新工艺 II Abstract This thesis includes four chapters as follows ： Chapter 1: Progress of Synthesis of p-acetylaminophenol The synthetic method of p-acetylaminophenol from different starting materials is reviewed in this chapter. Compared with different starting materials and methods,it was pointed out that the method from starting material phenol would be the better way for producing p-acetylaminophenol in veiw of economy and environment. Chapter2: Synthesis of p-acetylaminophenol through the new technology The high purity and yield p-acetylaminophenol was synthesized through zinc as antioxidant and catalyst, glacial acetic acid and p-aminophenol as raw materials in this chapter. Product was identified by analysis of m.p and H1 NMR. Finally the merit of the technology was reviewed. Chapter3: Synthesis of p-acetylaminophenol through the new one-pot method A new one-pot method for synthesis of p-acetylaminophenol from phenol，glacial acetic acid and hydroxylamine hydrochloride by Fries rearrangement over PPA catalyst and Beckmann rearrangment was studied in this chapter. Product was identified by analysis of m.p and H1