可降解甲壳质生物套管联合骨髓间充质干细胞移植修复脊髓损伤：可减少胶质瘢痕与空洞形成.docVIP

可降解甲壳质生物套管联合骨髓间充质干细胞修复脊髓损伤，生物套管间充质干细胞移植修复周围神经效果，可以有效促进神经再生。将外周神经应用效果良好的经过创新改进后联合骨髓间充质干细胞修复大鼠右侧脊髓半切损伤可以胶质瘢痕和脊髓空洞形成干预14周时损伤位点远近端有较多的神经纤维生长通过间充质干细胞体内移植后存活增殖情况良好干预8周时可分化为具有许旺细胞表型S100和胶质细胞表型的阳性细胞。 免疫荧光染色显示，生物套管联合骨髓间充质干细胞移植修复大鼠脊髓半切损伤后8周，细胞可分布于损伤脊髓近端（×4） Article: Biodegradable chitin conduit tubulation combined with bone marrow mesenchymal stem cell transplantation for treatment of spinal cord injury by reducing glial scar and cavity formation, by Feng Xue1, Er-jun Wu2, Pei-xun Zhang1, Li-ya A1, Yu-hui Kou1, Xiao-feng Yin1, Na Han3(1 Department of Trauma and Orthopedics, Peking University People’s Hospital, Beijing, China; 2 Graduate School of Shanxi Medical University, Taiyuan, Shanxi Province, China; 3 Central Laboratory, Peking University People’s Hospital, Beijing, China) Xue F, Wu EJ, Zhang PX, ALY, Kou YH, Yin XF, Han N (2015) Biodegradable chitin conduit tubulation combined with bone marrow mesenchymal stem cell transplantation for treatment of spinal cord injury by reducing glial scar and cavity formation. Neural Regen Res 10(1):104-111. 欲获更多资讯： Neural Regen Res Biodegradable chitin conduits with BMSCs reduce glial scar and cavity formation in SCI Previous studies have demonstrated that biodegradable chitin conduits or bone marrow mesenchymal stem cells (BMSCs) can be used to well repair peripheral nerve injuries and effectively promotes neural regeneration after spinal cord injury (SCI). Dr. Feng Xu, Peking University Peoples Hospital, China and his colleagues used modified biodegradable chitin conduits and BMSCs to repair rat right spinal cord transection. They found that a biological conduit combined with BMSCs transplantation effectively prevented scarring and reduced cavity formation. At 14 weeks after BMSCs transplantation, a large number of nerve fibers had grown through the injured spinal cord and BMSCs survived and proliferated after transplantation in vivo. At 8 weeks, the transplanted BMSCs differentiated into cells double positive for Schwann cell