《Best operating conditions to produce hydroxyapatite nanoparticles by means of a spinning disc reactor》.pdfVIP

Front．Chem．Sci．Eng．2014，8(2)：156—160 D0Il0．1007／sl1705—014．1427—9 Bestoperatingconditionstoproducehydroxyapatite nan0particIesbymeansofaspinningdiscreactor A．F．D’Intino，B．deCaprariis，M．L．Santarelli，N．Verdone，A．Chianese(函) DepartmentofChemicalEngineering，SapienzaUniversity，viaEudossiana00184Rome，Italy ◎HigherEducationPressandSpringer—VerlagBerlinHeidelberg2014 Abstract In this work，M g1。doped hydroxyapatite impacton themineralization process．1nfluencing both (Mg．HAP1nanoparticleswereproducedbyareaction． HAPcrysta1ofrmationandgrowthf2—4]，andincreasing precipitation processby using a spinning disc reactor theHAPdissolutioninhumanphysiologicmedium． fSDR1athighrotationalspeed．Theproductionprocessof Mg isthemostabundantcation inthecartilageand thesenanoparticlesconsistedoftheneutralizationreaction bonetissues．around6％mo1．anditsconcentrationtendsto betweenwt oaqueoussolutionsofcalcium chlorideand decreaseinmautrebone．ThedecreaseofM g amountin ammoniaOrthOphOsphateatroom temperature．Byoperat- bonetissuescausesthe cessation ofbone growth and ingatpH= 10．ahighpurityM g—HAPnanoparticleswere reductionofosteoblasticandoste：oclasticactivity f51． obtained．In particular,they were5lnm in averagesize Several works in literature deal with synthesis of when thetworeagentswere fedoverthedisc symme． M g—substiuttedHAP Among them．themostinteresting tricallyat3cm from thedisccenterandarotationa1speed onesconcem theadsorptionofMg(NO)，solutionson ofthediscreactorequalto1400r／minwasadopted． HAPsamples6『—11]，themechanochemicalsynthesisof powders[12]byreactionofMg(OH)2，Ca(OH)2and Keywords hydroxyapatite，nanoparticles，spinningdisc (NH4)，PO4andthemixingofMgOandHAP／tricalcium reactor phosphate(TCP)powders，withtheaim toimprovethe