《Characteristics of optic disc parameters and its association in normal Chinese population: the Handan Eye Study》.pdfVIP

《Characteristics of optic disc parameters and its association in normal Chinese population: the Handan Eye Study》.pdf

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《Characteristics of optic disc parameters and its association in normal Chinese population: the Handan Eye Study》.pdf

1702 ChinMedJ2014:127r9 Originalarticle Chhaarraacctteerriissttiiccssofo,DpttiiccddiiSsCcpoaarraammeettersaanndiittssaassssoocciiaattii~oni’nnormlaall Chinesepopulation:theHandanEyeStudy ZhangQing,LiSizhen,LiangYuanbo,WangFenghua,ChenWeiweiandWangNingli Keywords:opticdisc;primaryopen—angleglaucoma;myopia Background Assessmentoftheopticdiscandretinalnervefiberlayer(RNFL)isessentialforlhediagnosisand monitoringofglaucoma.Knowledgeofnormalopticdisctopographyprovidesabenchmarkforevaluatingglaucomatous pathologicchanges,especiallyin itsearlystages.Thepurposeofthisstudywastoevaluatethecharacteristicsand correlationfactorsoftheopticdiscparametersusingtheHeidelbergRetinaTomographII(HRTII)inalargesampleof normaleyesofadultChinesesubjects. Methods Discdatawereobtainedfr0m6830subjectsaged30yearsfromtheHandanEyeStudy~Allparticipants underwentcomprehensiveeyeexaminationsandphysicalexaminations.Theassociationsofgender,age,bodymass index.bloodpressure,waist-to-hipratio;refractiveerror,intraocularpressure,axiallength,anddiscareawereassessed usingsimpleandmultipleregressionanalysis.ThecorrelationbetweenHRT IIparameterswasevaluated. ResultsOfthe7557eligiblesubjects,6830tookpartinthestudy(90.4%responserate)and2633normaleyeswith good.qualityHRTIIimageswereselected.Themeandiscareawas2.28mm (standarddeviation(SD)0.43)andmean neuralrimareawas1.8Omm (SDO.29).Inmultipleregressionanalysis,opticdiscareasignificantlycorrelatedwithage, gender,andaxiaIlength(P0.001).Allopticdiscparametersshowedasignificantcorrelationwithdiscarea(0.054r 0.736,PO.01).TheassociationbewteenmeanRNFLthicknessandrimareaisstatisticallysignificantbutnotstrong fregressionlinearequation:rimarea=1.42xmeanRNFLthickness+1.32mm ,P0.001: =O.070).TheglobalRNFL cross.sectionalareawassignificantlyassociatedwithglobalrim area(regressionlinearequation:rim ar

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