p38促分裂原活化蛋白激酶在神经病理性疼痛中的作用.pdf

Chin J Clin Neurosci 2015, 23 (4),454~458,469 ·454 · 中国临床神经科学 2015 年第 23 卷第 4 期 进 展 p38 王依慰 1,2 ，李伟彦3 1 2 ( 徐州医学院江苏省麻醉学重点实验室， 徐州医学院江苏省麻醉与镇痛应用技术重点实验室 3 221004 ；南京军区南京总医院麻醉科 210002) 关键词　p38 促分裂原活化蛋白激酶；疼痛；敏感性；小胶质细胞 摘要 促分裂原活化蛋白激酶(MAPKs) 家族是细胞内重要的信号传导系统，并在神经可塑性以及炎症反应方面发挥 重要作用。MAPKs 家族包括3 个家庭成员：细胞外信号调节激酶、c-Jun 氨基末端激酶和p38MAPK 。p38 MAPK 信 号通路是MAPKs 家族信号通路的枢纽，诱导多种与神经性病理疼痛相关的细胞内反应。p38 MAPK 可以作为神经元 和胶质细胞中研究疼痛的靶标，为疼痛性疾病的治疗提供一个潜在治疗方案。 1,2 3 1Key Laboratory of The Potential Role of p38MAPK in the Neuropathic Pain WANG Yi-wei , LI Wei-yan Anesthesiology of Jiangsu Province, 2Key Laboratorg of Anesthesia and Analgesia Application Technology of Jiangsu Province, Xuzhou Medical College, Xuzhou 221004; 3Department of Anesthesiology, Nanjing General Hospital of Nanjing Military Command, Nanjing 210002, China KEY WORDS p38 MAPK; pain; sensitization; microglia ABSTRACT　Mitogen-activated protein kinases (MAPKs) mainly included extracellular signal- regulated kinas (ERKs) family, the c-Jun NH2-terminal kinases (JNKs) family and p38 MAPKs family. They play a well-recognized role in neural plasticity and inflammatory response. p38 MAPK signal transduction pathway is one of the multiple parallel MAPK signal transduction pathways, involving in the formation and maintenance of pain. p38 MAPK induces a variety of intracellular responses associated with neuropathic pain and other chronic pain. Thus, specific targeting p38 MAPK molecule and its signaling pathway represent potential therapeutic strategies for pain management. 疼痛可分为生理性疼痛和病理性疼痛。病理性