Relationship Between Atheroma Regression and Change in Lumen Size After Infusion of Apolipoprotein A-I Milano》.pdf

Journal of the American College of Cardiology Vol. 47, No. 5, 2006 © 2006 by the American College of Cardiology Foundation ISSN 0735-1097/06/$32.00 Published by Elsevier Inc. doi:10.1016/j.jacc.2005.11.040 Atherosclerosis Relationship Between Atheroma Regression and Change in Lumen Size After Infusion of Apolipoprotein A-I Milano Stephen J. Nicholls, MBBS, PHD, E. Murat Tuzcu, MD, Ilke Sipahi, MD, Paul Schoenhagen, MD, Tim Crowe, BS, Samir Kapadia, MD, Steven E. Nissen, MD Cleveland, Ohio OBJECTIVES The aim of this study was to determine the relationship between atheroma regression and arterial wall remodeling. BACKGROUND Infusion of reconstituted high-density lipoprotein (rHDL) containing recombinant apoli- poprotein A-I Milano (AIM) has been reported to promote rapid regression of coronary atherosclerosis. The current study analyzed intravascular ultrasound (IVUS) to define the changes that take place in the arterial wall that accompanied atheroma regression in this study. METHODS Forty-seven patients, ages 30 to 75 years, after an acute coronary syndrome were randomized to receive five weekly infusions of placebo or rHDL containing either low- or high-dose AIM. External elastic membrane (EEM) and lumen