社区癫患者的死亡风险（距基线调查12年后）随访研究.pdfVIP

中国临床神经科学 2015 年第 23 卷第 1 期 Chin J Clin Neurosci 2015, 23 (4), 366~371 ·366· Chin J Clin Neurosci 2015, 23 (3), 论 著 (12 ) 葛 炎，丁 玎，虞培敏，朱国行，洪 震 (复旦大学附属华山医院神经内科 200040) 关键词 癫 ；预后；病死率 摘要 目的　对社区癫 患者进行随访，获得其长期的死亡风险，并对相关影响因素进行分析。方法　对2002年复 旦大学附属华山医院和神经病学研究所在上海市金山区吕巷镇调查时确诊的65例癫 患者，于2014年(距基线调查时 间12年)以面见方式进行随访，由调查者收集资料、填写随访问卷，分析患者的长期预后情况。 　完成调查共计 结果 60例，失访5例(失访率7.7%) 。共发现死亡病例11/60例，病死率为18.3%(95%CI：10.0~29.6)；肿瘤是首要死因，占全 部死因的27.3% 。标化死亡比(SMR)为2.6(95%CI ：1.4~4.5) ，各年龄段中以40~45 岁的SMR最高(8.9) 。COX比例风险 回归模型分析显示部分性癫 发作(HR=5.4 ，95%CI ：1.2~24.0)是患者死亡的独立危险因素。结论　该社区癫 患者 的死亡风险是普通人群的2.6倍，肿瘤是首要死因。 Mortality of People with Epilepsy in a Community-based Cohort in Jinshan District, Shanghai: A Follow-up after 12 Years　GE Yan, DING Ding, YU Pei-min, ZHU Guo-xing, HONG Zhen Department of Neurology, Huashan Hospital, Fudan University, Shanghai 200040, China KEY WORDS epilepsy; prognosis; mortality ABSTRACT Aim To conducted a follow up the people with epilepsy (PWE) diagnosed in the prevalence study in Shanghai Jinshan District 12 years ago to observe the mortality of PWE. Methods A face-to-face interview to follow up the 65 PWE diagnosed in the prevalence study in Jinshan District, Shanghai, 2002 were carried out in 2014. Results 11 death cases were found in the cohort. The case fatality was 18.3% (95%CI 10.0-29.6). Tumor was the most common cause of death in the cohort, accounting for 27.3% of all death. The overall standardized mortality rate (SMR) was 2.56 (95%CI: 1.35-4.45). PWE with 40 to 45 years old suffered the highest SMR among all the age groups. COX reg